Table 3.

Associations of β and γ HPV species and types with risk of esophageal cancer

Cases (n = 125)Controls (n = 372)Adjusted modela
β HPV SpeciesbN (%)N (%)ORa (95% CI)PPermutated Pc
Any β HPV81 (64.8)205 (55.1)1.57 (1.00–2.47)0.0480.538
Any β 1 HPV59 (47.2)146 (39.3)1.49 (0.96–2.31)0.080.716
Any β 2 HPV64 (51.2)160 (43.0)1.34 (0.88–2.05)0.170.951
Any β 3 HPV24 (19.2)60 (16.1)1.26 (0.73–2.18)0.41>0.999
Specific β HPV typesb
β 1 HPV522 (17.6)42 (11.3)1.75 (0.97–3.16)0.070.655
 β 1 HPV1211 (8.8)27 (7.3)1.24 (0.58–2.65)0.58>0.999
 β 1 HPV2022 (17.6)46 (12.4)1.53 (0.87–2.70)0.140.908
 β 1 HPV3615 (12.0)33 (8.9)1.20 (0.61–2.35)0.60>0.999
 Clade of β 1 HPVs 5, 36, 47, & 14326 (20.8)59 (15.9)1.34 (0.79–2.27)0.280.995
 β 1 HPV10514 (11.2)29 (7.8)1.31 (0.65–2.63)0.45>0.999
 β 1 HPV12410 (8.0)28 (7.5)1.01 (0.46–2.21)0.99>0.999
 β 2 HPV2312 (9.6)26 (7.0)1.34 (0.64–2.81)0.44>0.999
 β 2 HPV378 (6.4)28 (7.5)0.97 (0.42–2.27)0.95>0.999
 β 2 HPV3824 (19.2)57 (15.3)1.28 (0.75–2.18)0.37>0.999
 β 2 HPV10717 (13.6)29 (7.8)1.85 (0.94–3.62)0.080.703
γHPV Speciesb
Any γ HPV53 (42.4)125 (33.6)1.38 (0.89–2.13)0.150.924
 Any γ 7 HPV20 (16.0)49 (13.2)1.11 (0.62–2.01)0.72>0.999
 Any γ 8 HPV13 (10.4)38 (10.2)1.02 (0.52–2.01)0.95>0.999
 Any γ 10 HPV13 (10.4)28 (7.5)1.33 (0.66–2.71)0.42>0.999
 Any γ 12 HPV8 (6.4)19 (5.1)1.34 (0.56–3.20)0.51>0.999
 Any γ 15 HPV13 (10.4)28 (7.5)1.39 (0.66–2.89)0.39>0.999
  • aOR and 95% CI were estimated from CLR models adjusted for smoking, alcohol consumption, and study cohort.

  • bβ and γ HPV species and types presented have a prevalence of 5% or higher either in cases or controls.

  • cPermutated P values were calculated to account for multiple comparisons (see methods).