Table 2.

HRs (95% confidence interval) for the relationship between the ERDP score and postmenopausal breast cancer in the Sister Study, 2003–2015

ERDP quartilesEstimate for continuous ERDP scorea
1st2nd3rd4th
Total breast cancer
 No. of cases520474484490
 Age adjusted1.00 (ref)0.92 (0.81–1.04)0.98 (0.86–1.11)1.03 (0.91–1.17)1.01 (0.95–1.08)
P = 0.71
 Age and energy adjusted1.00 (ref)0.93 (0.82–1.06)0.98 (0.87–1.11)1.01 (0.89–1.14)1.00 (0.94–1.06)
P = 0.94
 Multivariable adjustedb1.00 (ref)0.92 (0.81–1.04)0.96 (0.85–1.09)0.99 (0.87–1.12)0.98 (0.92–1.05)
P = 0.61
Invasive
 No. of cases393368350373
 Age adjusted1.00 (ref)0.95 (0.82–1.09)0.94 (0.81–1.08)1.05 (0.91–1.21)1.01 (0.94–1.09)
P = 0.71
 Age and energy adjusted1.00 (ref)0.97 (0.84–1.11)0.95 (0.82–1.10)1.01 (0.87–1.16)0.99 (0.92–1.07)
P = 0.84
 Multivariable adjustedb1.00 (ref)0.95 (0.82–1.09)0.92 (0.79–1.06)0.97 (0.84–1.12)0.97 (0.90–1.04)
P = 0.37
Invasive ER+
 No. of cases308268250272
 Age adjusted1.00 (ref)0.88 (0.75–1.04)0.86 (0.73–1.02)0.99 (0.84–1.16)0.98 (0.90–1.07)
P = 0.63
 Age and energy adjusted1.00 (ref)0.90 (0.76–1.06)0.87 (0.74–1.03)0.94 (0.80–1.11)0.96 (0.88–1.04)
P = 0.30
 Multivariable adjustedb1.00 (ref)0.88 (0.75–1.04)0.85 (0.71–1.00)0.91 (0.77–1.08)0.93 (0.86–1.02)
P = 0.11
Invasive ER−
 No. of cases47465256
 Age adjusted1.00 (ref)0.99 (0.66–1.49)1.14 (0.77–1.70)1.25 (0.85–1.85)1.16 (0.95–1.41)
P = 0.14
 Age and energy adjusted1.00 (ref)1.00 (0.66–1.50)1.15 (0.77–1.71)1.23 (0.83–1.82)1.15 (0.94–1.40)
P = 0.18
 Multivariable adjustedb1.00 (ref)0.99 (0.66–1.50)1.14 (0.76–1.69)1.21 (0.81–1.81)1.14 (0.93–1.40)
P = 0.20
Person years accumulated66,54566,11265,10064,201
  • aHR corresponds to 1-unit increase in ERDP score.

  • bIncludes adjustment for age, TEI, BMI, BMI at age 30, PHT, race/ethnicity, alcohol use, number of family members with a history of breast cancer, age at menarche, age at menopause, parity, and hysterectomy.