Table 4.

Associations of β and γ HPVs species and types with risk of histologic type of esophageal cancer

A. ESCC
Cases (n = 28)Controls (n = 83)Adjusted modela
N (%)N (%)ORa (95% CI)PPermutated Pc
β HPV speciesb
 Any β HPV14 (50.0)41 (49.4)1.05 (0.37–2.97)0.93>0.999
 Any β 1 HPV10 (35.7)27 (32.5)1.19 (0.42–3.35)0.75>0.999
 Any β 2 HPV11 (39.3)33 (39.8)0.99 (0.36–2.72)0.99>0.999
 Any β 3 HPV3 (10.7)19 (22.9)0.35 (0.1–1.48)0.150.792
Specific β HPV typesb
β 1 HPV55 (17.9)10 (12.1)1.56 (0.44–5.53)0.49>0.999
 β 1 HPV123 (10.7)9 (10.8)1.24 (0.26–5.79)0.79>0.999
 β 1 HPV203 (10.7)8 (9.6)1.10 (0.25–4.81)0.89>0.999
 β 1 HPV364 (14.3)6 (7.2)1.72 (0.36–8.14)0.50>0.999
 Clade of β 1 HPVs 5, 36, 47, & 1436 (21.4)12 (14.5)1.31 (0.39–4.39)0.66>0.999
 β 2 HPV232 (7.1)6 (7.2)1.31 (0.20–8.38)0.78>0.999
 β 2 HPV384 (14.3)16 (19.3)0.62 (0.18–2.11)0.45>0.999
γ HPV speciesb
 Any γ HPV12 (42.9)26 (31.3)1.31 (0.51–3.31)0.57>0.999
 Any γ 7 HPV3 (10.7)6 (7.2)0.81 (0.15–4.48)0.81>0.999
 Any γ 8 HPV3 (10.7)9 (10.8)0.61 (0.12–3.11)0.55>0.999
 Any γ 10 HPV4 (14.3)8 (9.6)1.46 (0.37–5.82)0.59>0.999
 Any γ 15 HPV3 (10.7)8 (9.6)1.22 (0.29–5.14)0.79>0.999
B. Esophageal adenocarcinoma
Cases (n = 80)Controls (n = 239)Adjusted modela
N (%)N (%)ORa (95% CI)PPermutated Pc
β HPV Speciesb
 Any β HPV56 (70.0)134 (56.1)1.84 (1.05–3.23)0.040.199
 Any β 1 HPV41 (51.3)94 (39.3)1.74 (1.00–3.04)0.050.296
 Any β 2 HPV42 (52.5)105 (43.9)1.34 (0.80–2.25)0.27>0.999
 Any β 3 HPV18 (22.5)34 (14.2)1.86 (0.95–3.63)0.070.363
Specific β HPV typesb
β 1 HPV514 (17.5)27 (11.3)1.78 (0.85–3.72)0.130.605
 β 1 HPV126 (7.5)16 (6.7)1.11 (0.42–2.93)0.83>0.999
 β 1 HPV2014 (17.5)31 (13.0)1.42 (0.70–2.91)0.33>0.999
 β 1 HPV3610 (12.5)23 (9.6)1.13 (0.50–2.55)0.77>0.999
 Clade of β 1 HPVs 5, 36, 47, & 14317 (21.3)39 (16.3)1.36 (0.71–2.58)0.35>0.999
 β 1 HPV10511 (13.8)20 (8.4)1.62 (0.72–3.63)0.24>0.999
 β 1 HPV1247 (8.8)20 (8.4)1.06 (0.42–2.67)0.90>0.999
 β 2 HPV239 (11.3)17 (7.1)1.67 (0.70–3.97)0.24>0.999
 β 2 HPV378 (10.0)21 (8.8)1.21 (0.49–2.97)0.68>0.999
 β 2 HPV3815 (18.8)34 (14.2)1.48 (0.75–2.92)0.26>0.999
 β 2 HPV10710 (12.5)19 (8.0)1.69 (0.72–3.98)0.23>0.999
γ HPV speciesb
 Any γ HPV32 (40.0)77 (32.2)1.53 (0.86–2.70)0.150.668
 Any γ 7 HPV13 (16.3)34 (14.2)1.12 (0.54–2.34)0.76>0.999
 Any γ 8 HPV4 (5.0)21 (8.8)0.43 (0.14–1.36)0.15>0.999
 Any γ 10 HPV7 (8.8)17 (7.1)1.38 (0.52–3.66)0.52>0.999
 Any γ 12 HPV7 (8.8)13 (5.4)1.92 (0.72–5.14)0.19>0.999
 Any γ 15 HPV8 (10.0)14 (5.9)1.93 (0.69–5.42)0.21>0.999
  • aOR and 95% CI were estimated from CLR models adjusted for smoking, alcohol consumption, and study cohort.

  • bβ and γ HPV species and types presented have a prevalence of 5% or higher either in cases or controls.

  • cPermutated P values were calculated to account for multiple comparisons (see methods).