Antibody positivity to Gallo2178 and colorectal cancer risk by p53 auto-antibody positivity and time between blood draw and diagnosis
| N | N (%) Gallo2178 pos | |||||
|---|---|---|---|---|---|---|
| Follow-up time | p53 autoantibody | Controls/cases | Controls | Cases | ORa (95% CI) | Pinteractiona |
| Overall | Neg | 3865/3797 | 156 (4) | 174 (5) | 1.15 (0.92–1.43) | |
| Pos | 198/266 | 7 (4) | 23 (9) | 2.74 (1.09–6.87) | 0.073 | |
| <10 years | Neg | 2614/2540 | 110 (4) | 139 (5) | 1.33 (1.02–1.72) | |
| Pos | 152/226 | 7 (5) | 21 (9) | 2.37 (0.92–6.09) | 0.315 | |
| ≥10 years | Neg | 1250/1256 | 46 (4) | 35 (3) | 0.74 (0.47–1.16) | |
| Pos | 46/40 | 0 (0) | 2 (5) | — | — | |
Abbreviations: Neg, negative; Pos, positive.
↵aUnconditional logistic regression model with adjustment for study, sex, race, and age; significant associations (P < 0.05) are marked in bold font.