Baseline characteristics of the cohorts participating in this study
| Variable | Total (N = 8,126) | Controls (n = 4,063) | Cases (n = 4,063) |
|---|---|---|---|
| Study, n (%) | |||
| CLUE | 982 (12) | 491 (12) | 491 (12) |
| CPS-II | 722 (9) | 361 (9) | 361 (9) |
| HPFS | 302 (4) | 151 (4) | 151 (4) |
| MEC | 1,510 (19) | 755 (19) | 755 (19) |
| NHS | 576 (7) | 288 (7) | 288 (7) |
| NYUWHS | 572 (7) | 286 (7) | 286 (7) |
| PHS | 360 (4) | 180 (4) | 180 (4) |
| PLCO | 1,240 (15) | 620 (15) | 620 (15) |
| SCCS | 252 (3) | 126 (3) | 126 (3) |
| WHI | 1,610 (20) | 805 (20) | 805 (20) |
| Age at blood draw (years) | |||
| Median (range) | 64 (18–89) | 64 (18–88) | 64 (18–89) |
| Sex, n (%) | |||
| Female | 5,112 (63) | 2,556 (63) | 2,556 (63) |
| Male | 3,014 (37) | 1,507 (37) | 1,507 (37) |
| Race/ethnicity, n (%) | |||
| White | 6,134 (75) | 3,067 (75) | 3,067 (75) |
| African American | 798 (10) | 399 (10) | 399 (10) |
| Asian American | 614 (8) | 307 (8) | 307 (8) |
| Latino | 422 (5) | 211 (5) | 211 (5) |
| Other/unknown/multiracial | 158 (2) | 79 (2) | 79 (2) |
| Education, n (%) | |||
| Less than HS | 972 (12) | 468 (12) | 504 (12) |
| Completed HS or GED | 1,668 (21) | 823 (20) | 845 (21) |
| Post HS training other than college | 362 (4) | 183 (5) | 179 (4) |
| Some college | 1,672 (21) | 845 (21) | 827 (20) |
| College graduate | 1,483 (18) | 756 (19) | 727 (18) |
| Graduate school | 1,861 (23) | 946 (23) | 915 (23) |
| Missing | 108 (1) | 42 (1) | 66 (2) |
| BMIa (kg/m2), n (%) | |||
| <30 | 5,360 (66) | 2,781 (69) | 2,579 (64) |
| ≥30 | 1,691 (21) | 748 (18) | 943 (23) |
| Missing | 1,075 (13) | 534 (13) | 541 (13) |
| Smoking, n (%) | |||
| Never | 3,628 (45) | 1,853 (46) | 1,775 (44) |
| Ever | 4,409 (54) | 2,168 (53) | 2,241 (55) |
| Missing | 89 (1) | 42 (1) | 47 (1) |
| Family history of CRCb, n (%) | |||
| No | 5,167 (64) | 2,638 (65) | 2,529 (62) |
| Yes | 907 (11) | 408 (10) | 499 (12) |
| Missing | 2,052 (25) | 1,017 (25) | 1,035 (26) |