Table 1.

Prostate cancer–associated variants discovered through GWAS

SNP IDBandAllelesaRAFORReference/PMID
63 novel SNPs identified on the OncoArray
 rs563910741p22.3A/AT0.3791.054
 rs345794421q21.3C/CT0.3361.074
 rs747026812p14T/C0.0221.154
 rs621066702p25.1T/C0.3791.054
 rs116915172q13T/G0.7411.054
 rs349255932q31.1C/T0.4811.064
 rs593089632q33.1T/TATTCTGTC0.7291.054
 rs12831043q13.12G/C0.3791.044
 rs1823143343q25.1T/C0.8951.104
 rs1424367493q26.2G/A0.0121.234
 rs107938215q31.1T/C0.5731.054
 rs765518435q35.1A/G0.9911.334
 rs49767905q35.3T/G0.1131.094
 rs47117486p21.1T/C0.2251.054
 rs94698996p21.31A/G0.3571.054
 rs92960686p21.32T/G0.6511.054
 rs126653396p21.33G/A0.1671.064
 rs176213457p14.1A/C0.7411.074
 rs114526867p21.1T/TA0.5581.044
 rs5275107167p22.3C/G0.2411.074
 rs101224959p13.3T/A0.291.054
 rs10481699p22.1C/T0.3791.074
 rs11829q34.11A/C0.2201.074
 rs14153608710p15.3GCGCA/G0.1501.104
 rs193558110q23.31C/T0.6231.064
 rs709487110q25.2G/C0.5371.044
 rs54717108111p11.2CGG/C0.4701.054
 rs188150211p15.5T/C0.1901.064
 rs6189018411p15.4A/G0.1241.084
 rs227728311q12.3C/T0.3131.064
 rs1278590511q13.2C/G0.0481.094
 rs1129095411q13.5AC/A0.6761.074
 rs180005711q22.3G/C0.0251.134
 rs13846603911q24.2T/C0.011.284
 rs87898711q25G/A0.1461.074
 rs206682712p13.1T/G0.7551.074
 rs1084593812p13.1G/A0.5511.064
 rs796840312q14.2T/C0.6431.074
 rs579992112q21.33GA/G0.6991.084
 rs729501412q24.33G/A0.341.064
 rs100403014q11.2T/C0.591.044
 rs1162941214q13.3C/G0.5781.064
 rs492448715q15.1C/G0.841.064
 rs3398405915q21.3A/G0.9781.204
 rs11229387615q22.31C/CA0.2891.074
 rs1186370916q21C/T0.9601.174
 rs20115809316q23.3TAA/TA0.4401.054
 rs2844155817p13.1C/T0.0561.144
 rs14244426917q11.2C/T0.7881.084
 rs268070817q22G/A0.6051.044
 rs809360118q21.2C/G0.441.044
 rs2860766218q21.2C/T0.0961.074
 rs1295689218q21.32T/G0.301.054
 rs53372230818q21.33CT/C0.4121.054
 rs1046010918q22.3T/C0.421.044
 rs1166656919p13.11C/T0.7111.064
 rs11800550319q12G/C0.9111.114
 rs6108813119q13.2T/C0.8351.054
 rs1148045320q11.21C/CA0.6021.054
 rs609175820q13.2G/A0.4641.094
 rs962548322q12.1A/G0.0271.174
 rs1732148223p22.2C/T0.8661.074 
 rs138004030b6q27G/A0.921.284
SNPs discovered in European populations
 rs6362911A0.6831.0425217961
 rs175996291G0.2181.0725217961
 rs12185821G0.44671.0523535732
 rs42457391A0.7381.1020197460, 23535732
 rs119022362T0.2691.0523535732
 rs92877192C0.4671.0725217961
 rs93068952C0.3641.0826025378
 rs14656182T0.21411.0919767753
 rs7210482A0.18221.1018264098
 rs101874242T0.57381.0821743467
 rs126212782A0.94141.2719767753
 rs22928842G0.24131.0621743057
 rs37715702T0.14951.0923535732
 rs26607533T0.10281.1318264097
 rs76116943A0.5791.0923535732
 rs109348533A0.2771.1019767754
 rs67639313A0.4421.0421743467
 rs109366323A0.50741.1021743467
 rs100094094T0.3111.0625217961
 rs18942924G0.5151.0623535732
 rs125004264A0.46321.0719767753
 rs170219184C0.65071.0919767753
 rs76796734C0.5921.1319767753
 rs22426525G0.7941.1721743467
 rs21218755C0.331.0521743467
 rs68698415T0.2091.0423535732
 rs47132666C0.5171.0525217961
 rs77671886A0.2101.0625217961
 rs1300676G0.20211.0521743467
 rs30967026A0.37711.0623535732
 rs31298596G0.6701.0625217961
 rs22736696G0.14621.0723535732
 rs19334886A0.57881.0823535732
 rs93645546T0.28261.1118264097
 rs121551727A0.2201.1023535732
 rs104865677G0.7631.1418264096
 rs562325067A0.4511.0625217961
 rs64656577C0.46351.1118264097
 rs29286798A0.4371.0519767753
 rs111359108T0.15291.0823535732
 rs125436638C0.2951.1219767752
 rs100869088T0.6971.1319767752
 rs1833730248G0.0072.9123104005
 rs169019798A0.0321.5617401366
 rs6208618G0.6311.1519767752
 rs69832678G0.5111.2217401363
 rs14472958A0.1071.4117401363, 17401366
 rs176944939G0.1361.0825217961
 rs15718019T0.2681.0318073375
 rs7693403410T0.9171.1225217961
 rs1099399410T0.3831.2318264096, 18264097
 rs385069910A0.7001.0723535732
 rs496241610C0.26681.0618264096
 rs712790011A0.19851.1919767753
 rs793134211G0.5041.1718264097
 rs1156881811T0.5501.0823535732
 rs1121477511G0.7091.0725217961
 rs8013081912A0.9081.1025217961
 rs1087594312C0.2871.0721743467
 rs90277412A0.15261.1321743057
 rs127088412A0.4821.0723535732
 rs800827014C0.81391.0923535732
 rs714152914C0.4991.0523535732
 rs801467114G0.5801.0525217961
 rs68423217C0.35341.0923535732
 rs1164974317G0.80551.1318758462
 rs443079617A0.52531.2217603485
 rs13821319717T0.0023.8522236224
 rs1165049417A0.07791.1023535732
 rs185996217G0.48131.1717603485
 rs724199318C0.69491.0823535732
 rs810247619C0.53931.0919767754
 rs1167269119G0.73681.1019318570, 23065704
 rs273583919G0.85271.1818264097
 rs242734520C0.6211.0523535732
 rs606250920T0.69831.0823535732
 rs5813363522T0.1971.0719117981, 25217961
 rs575916722G0.5021.1519767753
 rs240594223A0.78331.0523535732
 rs594561923C0.3641.1118264097
 rs280703123C0.1821.0625217961
 rs591943223T0.80081.0421743467
 rs662571123A0.17631.0125217961
 rs484428923G0.3841.0425217961
SNPs discovered in non-European populations
 rs20551093T0.76431.0222366784
 rs126539465T0.42461.0820676098
 rs19838916T0.27731.0920676098
 rs3393316T0.6951.0920676098
 rs15122688T0.42961.1420676098
 rs8178269T0.85521.0023023329
 rs225200410A0.10171.0022366784
 rs1279144711G0.07471.0526443449
 rs193878111G0.22971.0322366784
 rs960007913T0.4431.0120676098
 rs5826236914C0.9981.2726443449
 rs721010017A0.00011.3421602798
 rs10329419C0.78121.0023023329
 rs7582304413T0.0221.55Reference (22)
 rs7855404322C0.0151.62Reference (22)
SNPs discovered in multi-ancestry populations
 rs17751481C0.3591.0425217961
 rs94431896A0.8571.0725217961
 rs715364814C0.0821.0325217961
 rs1205144316A0.3441.0325217961
 rs1248032820T0.9281.1125217961
 rs104144921G0.4331.0525217961
 rs223877622G0.8021.0525217961
  • Abbreviations: PrCa, prostate cancer; RAF, risk allele frequency.

  • aReference allele/risk allele.

  • bAssociated with early-onset PrCa.