Table 3.

Comparison with commercially available molecular assays

Molecular assay/reportSensitivitySpecificityNPVPPVComments
Afirma GEC (5)92%52%93%47%Multiple validation studies
Afirma GSC91%68%96%%47%One meta-analysis
 Other reported results83%–100%10%–73%75%–100%14%–57%
ThyroSeq v2 (7)90%93%96%83%Limited validation data
 Other reported results70%–95%60%–77%91%–98%27%–66%
Rosetta (6)74%–100%74%–80%92%–100%41%–43%Difference between the entire and agreement validation sets
Current study91%100%87%100%