Table 1.

Patient- and tumor-related characteristics and survival outcomes according to mode of detectiona

Screen-detected cancers (n = 195)Interval cancers (n = 179)True interval cancers (n = 88)False negatives (n = 43)Occult tumors (n = 25)Minimal sign cancers (n = 23)
n (%)n (%)Pbn (%)n (%)n (%)n (%)Pc
Age group (y)
 50–59 years92 (47.2)115 (64.2)59 (67.0)27 (62.8)15 (60.0)14 (60.9)
 60–69 years103 (52.8)64 (35.8)0.00129 (33.0)16 (37.2)10 (40.0)9 (39.1)0.021
Breast density (%)
 Non-dense breasts (< 25%)113 (57.9)79 (44.1)37 (42.0)25 (58.1)6 (24.0)11 (47.8)
 Mixed dense breasts (≥ 25%)82 (42.1)100 (55.9)0.00851 (58.0)18 (41.9)19 (76.0)12 (52.2)0.005
TNM stage
 I108 (56.0)53 (30.1)25 (28.4)15 (34.8)8 (32.0)5 (23.8)
 II63 (32.6)78 (44.3)36 (40.9)20 (46.5)9 (36.0)13 (61.9)
 III19 (9.8)41 (23.3)25 (28.4)7 (16.3)6 (24.0)3 (14.3)
 IV3 (1.6)4 (2.3)<0.0012 (2.3)0 (0)2 (8.0)0 (0)<0.001
Phenotype
 Luminal type A73 (47.4)82 (48.8)36 (42.4)19 (48.7)15 (65.2)12 (57.1)
 Luminal type B49 (31.8)43 (25.6)21 (24.7)11 (28.2)5 (21.7)6 (28.6)
 HER212 (7.8)19 (11.3)13 (15.3)4 (10.3)1 (4.3)1 (4.8)
 Triple-negative20 (13.0)24 (14.3)0.5215 (17.6)5 (12.8)2 (8.7)2 (9.5)0.611
Vital status
 Alive without disease156 (80.0)132 (73.7)65 (73.9)32 (74.4)17 (68.0)18 (78.3)
 Alive with disease18 (9.2)10 (5.6)3 (3.4)2 (4.7)2 (8.0)3 (13.0)
 Exitus21 (10.8)37 (20.7)0.01820 (22.7)9 (20.9)6 (24.0)2 (8.7)0.103
  • aTumors with missing information were excluded for the calculation of percentage.

  • bScreen-detected and interval cancers are compared with.χ2 two-sided test or Fisher's exact two-sided test.

  • cScreen-detected, true interval, and false negative cancers are compared with χ2 two-sided test or Fisher's exact two-sided test.