Table 2.

SNPs associated with radiation toxicity

Locus nearest gene(s)SNPToxicity endpointOR (95% confidence interval)Proposed mechanistic relationshipReference
5q31.2 – KDM3Brs17599026Urinary frequency (2 years after RT)3.12 (2.08–4.69)KDM3B expressed in bladder tissue. Radiation may lead to bladder dysfunction due to effect on this gene.25
5p15.2 – DNAH5rs7720298Decreased urine stream (2 years after RT)2.71 (1.90–3.86)DNAH5 expressed in kidney and bladder tissue. Radiation may lead to bladder dysfunction due to effect on this gene.24
2q24.1 - TANC1rs264663Overall toxicity, late toxicity6.6 (2.2–19.6)TANC1 involved in repair of muscle damage.26
9p21.2 - IFNK and MOB3Brs17779457 (1 of 8 SNPs in a haplotype block)Urinary symptoms e.g., incomplete emptying, intermittency, frequencyNo OR published. Beta coefficient 2.4IFNK a member of type 1 IFN family with a role in inflammatory response to radiation-induced tissue damage.27
MOB3B essential for mitotic checkpoint regulation.
11q14.3 -rs7120482Rectal bleeding3.1 (1.7–5.6)SLC36A4 encodes an amino acid transporter28
SLC36A4rs176306382.9 (1.6–5.2)needed for cellular proliferation.
Chr 2 - FSHRrs2268363 (GWAS in African American men)Erectile dysfunctionOR = 7.03; 95% CI 3.4–14.7Involved in normal testis development. Disruption of FSH signaling associated with abnormal spermatogenesis and infertility.29
10q26.3 - GLRX3rs11017104Erectile dysfunction1.5 (0.7–3.0)12 SNPs identified that lie near genes involvedin biological activities of erectile function.30
19q13.43 - NLRP11rs7245988 (2 of 12 SNPs discovered in this GWAS)2.0 (0.9–4.4)
  • Abbreviation: RT, radiotherapy.