Table 2.

Cox regression HRs of cancer incidence by cancer site and total PA (MET-hours per week) in quartiles

MET-hours per weekCasesAge-adjusted HR (95% CI)CasesMultivariate-adjusted HRa (95% CI)CasesLatency multivariate-adjusted HRb (95% CI)
All-cancer
 0–113.77631.0 (Ref)7291.0 (Ref)6251.0 (Ref)
 113.8–152.95000.89c (0.79–1.00)4870.93 (0.83–1.04)4240.94 (0.83–1.06)
 153.0–201.14870.94 (0.84–1.06)4660.96 (0.85–1.08)3980.94 (0.83–1.07)
 201.2–535.34360.88c (0.78–0.99)4250.87c (0.76–0.99)3720.87c (0.76–1.00)
Ptrend0.080.060.06
Breast cancer
 0–113.71491.0 (Ref)1411.0 (Ref)1231.0 (Ref)
 113.8–152.91120.85 (0.66–1.09)1100.86 (0.67–1.11)990.88 (0.67–1.16)
 153.0–201.11080.92 (0.71–1.18)1010.90 (0.69–1.17)890.89 (0.67–1.18)
 201.2–535.3830.83 (0.63–1.09)810.85 (0.64–1.14)690.82 (0.60–1.12)
Ptrend0.250.320.23
Colon cancer
 0–113.7781.0 (Ref)741.0 (Ref)641.0 (Ref)
 113.8–152.9240.43d (0.27–0.69)240.47d (0.29–0.75)220.50d (0.30–0.81)
 153.0–201.1390.78 (0.52–1.16)390.82 (0.55–1.24)340.81 (0.52–1.26)
 201.2–535.3400.83 (0.55–1.24)400.83 (0.54–1.26)330.76 (0.48–1.20)
Ptrend0.510.540.35
Prostate cancer
 0–113.71151.0 (Ref)1131.0 (Ref)901.0 (Ref)
 113.8–152.9781.16 (0.86–1.56)781.15 (0.85–1.54)661.19 (0.86–1.65)
 153.0–201.1911.32e (0.99–1.77)881.27 (0.95–1.71)761.35e (0.97–1.86)
 201.2–535.3821.08 (0.80–1.46)791.08 (0.79–1.48)701.14 (0.81–1.60)
Ptrend0.400.440.32
Lung cancer
 0–113.7861.0 (Ref)821.0 (Ref)691.0 (Ref)
 113.8–152.9440.85 (0.58–1.22)410.95 (0.65–1.39)350.92 (0.61–1.40)
 153.0–201.1320.73 (0.48–1.11)290.71 (0.46–1.10)270.82 (0.52–1.30)
 201.2–535.3290.73 (0.47–1.14)290.76 (0.48–1.21)260.79 (0.49–1.28)
Ptrend0.100.120.28
Endometrial cancer
 0–113.7431.0 (Ref)371.0 (Ref)331.0 (Ref)
 113.8–152.9411.07 (0.69–1.65)381.38 (0.86–2.22)311.22 (0.73–2.03)
 153.0–201.1170.50c (0.28–0.88)140.62 (0.33–1.18)130.62 (0.32–1.21)
 201.2–535.3160.54c (0.30–0.98)150.77 (0.41–1.46)130.71 (0.36–1.40)
Ptrend0.010.150.13
Non-Hodgkin lymphoma
 0–113.7361.0 (Ref)351.0 (Ref)331.0 (Ref)
 113.8–152.9180.63 (0.35–1.12)170.65 (0.36–1.18)160.65 (0.35–1.21)
 153.0–201.1180.67 (0.37–1.20)180.69 (0.38–1.26)110.46c (0.22–0.93)
 201.2–535.3210.79 (0.45–1.40)210.72 (0.40–1.30)200.73 (0.40–1.36)
Ptrend0.390.280.19
Leukemia
 0–113.7281.0 (Ref)261.0 (Ref)181.0 (Ref)
 113.8–152.9221.05 (0.59–1.86)211.09 (0.60–1.97)201.49 (0.77–2.86)
 153.0–201.1211.09 (0.61–1.96)211.13 (0.62–2.07)171.32 (0.66–2.63)
 201.2–535.3191.01 (0.55–1.87)191.01 (0.53–1.92)181.36 (0.68–2.75)
Ptrend0.920.920.47
Hematologic cancers
 0–113.7651.0 (Ref)621.0 (Ref)521.0 (Ref)
 113.8–152.9410.81 (0.54–1.21)390.84 (0.55–1.26)370.95 (0.61–1.6)
 153.0–201.1400.85 (0.56–1.28)400.87 (0.58–1.33)290.76 (0.47–1.22)
 201.2–535.3400.87 (0.57–1.31)400.82 (0.53–1.26)380.93 (0.59–1.46)
Ptrend0.510.400.52
  • aAdjusted for: age (continuous), sex (for non–sex-specific cancers), ethnicity (white/other), marital status (married or living with someone/divorced, separated, or widowed/single, never married), highest level of education (high school or less/some post–high school education/post–high school certificate or degree), total household income ($0 to $49,999/$50,000 to $99,999/≥ $100,000), geographical area of residence (urban/rural), smoking status (current/former/never), pack-years of cigarettes (lung cancer only), alcohol consumption (grams of ethanol per day), energy intake (kilocalories per day), fiber intake (grams per day) (colon cancer only), BMI (continuous), history of cardiovascular condition (yes/no), history of respiratory condition (yes/no), family history of cancer (yes/no), menopausal status (premenopause/postmenopause) (breast and endometrial cancers), history of breast cancer screening (yes/no) (breast cancer only), history of colon cancer screening (yes/no) (colon cancer only), and history of prostate cancer screening (yes/no) (prostate cancer only).

  • bCancers occurring less than 2 years after baseline data collection removed.

  • cP < 0.05.

  • dP < 0.01.

  • eP < 0.1.