Table 3.

Odds ratios for breast cancer among cancer patients who either have AML or breast cancer by the presence or absence of point mutations in driver genes that either are, or are not, regulated by E2-ESR1

AMLBreast cancer
Number (%)Number (%)ORP95% CI
No mutations in regulated genesa228 (16.3)8 (1.7)1.0c
At least one mutation in regulated genesa1,175 (83.7)470 (98.3)11.42.9 × 10−226.0–25
Total1,403 (100)478 (100)
No mutations in unregulated genesb419 (29.9)330 (69.0)1.0c
At least one mutation in unregulated genesb984 (70.1)148 (31.0)0.1913.4 × 10−510.15–0.24
Total1,403 (100)478 (100)
At least one mutation in unregulated genesb9841481.0c
At least one mutation in regulated genesa1,17547022.42.4 × 10−1711–46
  • aGenes regulated by E2-ESR1.

  • bGenes not regulated by E2-ESR1.

  • cDenominator of following odds ratio.