Table 1.

Demographic and clinical characteristics of molecular subtypes in women with invasive breast cancer (SEER-18 excluding Alaska, 2010–2013)

All casesAmong cases with known subtype (N = 179,098)aAmong total casesb
HR+/HER2Triple-negativeHR+/HER2+HR/HER2+Unknown subtype
N = 196,094N = 130,543 (66.6%)N = 21,136 (10.8%)N = 19,016 (9.7%)N = 8,403 (4.3%)N = 16,996 (8.7%)
Demographic characteristics
 Age at diagnosis
  <5044,64826,819 (64.9%)6,171 (14.9%)5,970 (14.5%)2,346 (5.7%)3,342 (7.5%)
  50–6475,78849,872 (71.4%)8,400 (12.0%)7,784 (11.2%)3,748 (5.4%)5,984 (7.9%)
  65–7442,71330,857 (78.8%)3,785 (9.7%)3,154 (8.1%)1,375 (3.5%)3,542 (8.3%)
  75+32,94522,995 (79.8%)2,780 (9.6%)2,108 (7.3%)934 (3.2%)4,128 (12.5%)
 Race/ethnicity
  Non-Hispanic white133,23892,323 (75.6%)12,710 (10.4%)12,205 (10.0%)4,932 (4.0%)11,068 (8.3%)
  Non-Hispanic black21,73912,035 (61.1%)4,230 (21.5%)2,283 (11.6%)1,147 (5.8%)2,044 (9.4%)
  Non-Hispanic API16,71210,889 (71.3%)1,430 (9.4%)1,900 (12.4%)1,062 (6.9%)1,431 (8.6%)
  Hispanic22,37314,088 (69.6%)2,575 (12.7%)2,417 (11.9%)1,169 (5.8%)2,124 (9.5%)
 Poverty 2010 (county level)
  High SES31,37021,649 (75.2%)2,923 (10.2%)2,902 (10.1%)1,321 (4.6%)2,575 (8.2%)
  Medium SES136,61291,229 (73.2%)14,476 (11.6%)13,213 (10.6%)5,789 (4.6%)11,905 (8.7%)
  Low SES28,06517,638 (69.0%)3,735 (14.6%)2,899 (11.3%)1,292 (5.1%)2,501 (8.9%)
 Urban 2010 (county level)
  Less urban (< 50%)14,5869,289 (70.8%)1,790 (13.6%)1,433 (10.9%)612 (4.7%)1,462 (10.0%)
  More urban (≥ 50%)181,461121,227 (73.1%)19,344 (11.7%)17,581 (10.6%)7,790 (4.7%)15,519 (8.6%)
 Insurance status
  Uninsured4,0622,255 (63.6%)591 (16.7%)470 (13.3%)230 (6.5%)516 (12.7%)
  Any medicaid23,16713,919 (66.3%)3,148 (15.0%)2,585 (12.3%)1,328 (6.3%)2,187 (9.4%)
  Insured137,98094,693 (74.0%)14,315 (11.2%)13,225 (10.3%)5,658 (4.4%)10,089 (7.3%)
  Insured/no specifics26,20817,312 (73.7%)2,736 (11.6%)2,406 (10.2%)1,046 (4.5%)2,708 (10.3%)
  Unknown4,6772,364 (74.3%)346 (10.9%)330 (10.4%)141 (4.4%)1,496 (32.0%)
 Year of diagnosis
  201047,09430,365 (72.1%)5,233 (12.4%)4,492 (10.7%)2,000 (4.8%)5,004 (10.6%)
  201149,02332,576 (73.0%)5,398 (12.1%)4,538 (10.2%)2,089 (4.7%)4,422 (9.0%)
  201249,54633,274 (72.9%)5,322 (11.7%)4,890 (10.7%)2,150 (4.7%)3,910 (7.9%)
  201350,43134,328 (73.4%5,183 (11.1%)5,096 (10.9%)2,164 (4.6%)3,660 (7.3%)
 Marital status
  Single29,18818,327 (69.3%)3,574 (13.5%)3,205 (12.1%)1,329 (5.0%)2,753 (9.4%)
  Married105,95571,630 (72.9%)11,247 (11.5%)10,724 (10.9%)4,623 (4.7%)7,731 (7.3%)
  Separated2,0401,264 (68.4%)264 (14.3%)218 (11.8%)103 (5.6%)191 (9.4%)
  Divorced20,64813,793 (72.4%)2,367 (12.4%)1,962 (10.3%)921 (4.8%)1,605 (7.8%)
  Widowed26,39118,136 (77.3%)2,481 (10.6%)1,898 (8.1%)940 (4.0%)2,936 (11.1%)
  Unknown11,4487,097 (73.2%)1,160 (12.0%)964 (9.9%)471 (4.9%)1,756 (15.3%)
Clinical characteristics
 AJCC 7th stage
  I92,64169,202 (80.4%)7,076 (8.2%)7,135 (8.3%)2,632 (3.1%)6,596 (7.1%)
  II62,90540,280 (68.1%)8,986 (15.2%)6,960 (11.8%)2,952 (5.0%)3,727 (5.9%)
  III22,42013,142 (62.4%)3,274 (15.5%)2,920 (13.9%)1,740 (8.3%)1,344 (6.0%)
  IV11,1405,557 (60.3%)1,311 (14.2%)1,516 (16.4%)837 (9.1%)1,919 (17.2%)
  Unknown6,6082,355 (67.1%)462 (13.2%)470 (13.4%)223 (6.4%)3,098 (46.9%)
 Bloom–Richardson grade
  Low grade44,03238,652 (93.1%)948 (2.3%)1,551 (3.7%)358 (0.9%)2,523 (5.7%)
  Medium grade72,88157,018 (82.7%)3,349 (4.9%)6,797 (9.9%)1,743 (2.5%)3,974 (5.5%)
  High grade52,03322,156 (45.0%)14,079 (28.6%)8,137 (16.5%)4,877 (9.9%)2,784 (5.4%)
  Unknown27,14812,717 (65.4%)2,760 (14.2%)2,531 (13.0%)1,425 (7.3%)7,715 (28.4%)
 Tumor size
  <2.0 cm109,85580,779 (79.2%)8,711 (8.5%)9,058 (8.9%)3,503 (3.4%)7,804 (7.1%)
  2.0–4.9 cm61,22437,756 (65.9%)9,048 (15.8%)7,286 (12.7%)3,239 (5.6%)3,895 (6.4%)
  5.0+ cm16,1858,925 (60.6%)2,643 (17.9%)1,957 (13.3%)1,211 (8.2%)1,449 (9.0%)
  Unknown8,8303,083 (61.9%)734 (14.7%)715 (14.4%)450 (9.0%)3,848 (43.6%)
 Nodal status
  Positive63,63240,058 (67.1%)7,713 (12.9%)7,978 (13.4%)3,976 (6.7%)3,907 (6.14%)
  Negative127,24088,843 (76.0%)13,120 (11.2%)10,713 (9.2%)4,277 (3.7%)10,287 (8.08%)
  Unknown5,2221,642 (67.9%)303 (12.5%)325 (13.4%)150 (6.2%)2,802 (53.66%)
  • aPercent calculated among cases with a known breast cancer molecular subtype.

  • bPercent calculated among total cases.