Table 2.

Summary of secondary analyses for metformin and all-cause mortality

naHR (95% CI)PI2
Time-related biasesNo bias40.75 (0.58–0.98)0.0481%
Bias120.48 (0.40–0.59)<0.0000117%
RoB of studiesLow RoB70.55 (0.36–0.83)0.00485%
High RoB90.58 (0.49–0.71)<0.0000135%
BMI/obesityAdjusted110.50 (0.43–0.59)<0.000010%
Unadjusted50.74 (0.55–1.01)0.0677%
  • aNumber of effect sizes pooled.