Table 3.

Number of cases (assuming an equal number of controls) required to detect an OR with 80% power and a disease prevalence of 1% assuming 1, 2, or 3 oral samples per subject based on the ICC estimated from the OMNIgene ORAL samples with a P value threshold of 0.05

				OR
		Estimated ICC	#Specimens per subject	1.50	2.00	2.50	3.00	3.50
Relative abundance of phylum-level taxa	Actinobacteria	0.46	1	1431	477	261	181	144
			2	1045	348	190	132	105
			3	916	305	167	116	92
	Bacteroidetes	0.62	1	1062	354	193	134	107
			2	860	286	157	109	87
			3	793	264	144	100	80
	Firmicutes	0.44	1	1496	498	273	190	151
			2	1077	359	196	136	109
			3	938	312	171	119	94
	Fusobacteria	0.67	1	983	327	179	124	99
			2	820	273	149	104	83
			3	766	255	140	97	77
	Proteobacteria	0.67	1	983	327	179	124	99
			2	820	273	149	104	83
			3	766	255	140	97	77
	Candidate division SR1	0.73	1	902	300	164	114	91
			2	780	260	142	99	79
			3	739	246	135	93	74
Alpha diversity	Chao1	0.73	1	902	300	164	114	91
			2	780	260	142	99	79
			3	739	246	135	93	74
	PD whole tree	0.45	1	1463	487	267	185	148
			2	1061	353	193	134	107
			3	926	308	169	117	93
	Observed species	0.74	1	890	296	162	113	90
			2	774	258	141	98	78
			3	735	245	134	93	74
	Shannon index	0.56	1	1176	392	214	149	119
			2	917	305	167	116	92
			3	831	277	151	105	84
Beta diversity	Bray Curtis distance	0.70	1	940	313	171	119	95
			2	799	266	146	101	80
			3	752	250	137	95	76
	Unweighted UniFrac distance	0.64	1	1029	343	187	130	104
			2	843	281	154	107	85
			3	782	260	142	99	79
	Weighted UniFrac distance	0.67	1	983	327	179	124	99
			2	820	273	149	104	83
			3	766	255	140	97	77