Table 1.

Risk associated with overall breast cancer for 172 SNPs

Overall breast cancer risk (24)
LocusLocus discovery referenceaGenesrs IDAllelesMAFbRefined SNP referencecSubtypedORe (95% CI)fPgCombined Ph
2q33.1(99)CASP8/ALS2CR12rs1830298T/C0.28(100)Overall1.06 (1.04–1.08)1.7 × 10−081.9 × 10−16
5q11.2(12)MAP3K1rs62355902A/T0.16(12)Overall1.18 (1.15–1.21)8.5 × 10−426.8 × 10−98
8q24.21(12)rs13281615A/G0.41(12)Overall1.11 (1.09–1.13)5 × 10−281.9 × 10−57
11p15.5(12)LSP1rs3817198T/C0.32(12)Overall1.05 (1.03–1.07)6.2 × 10−079.9 × 10−19
16q12.1(12)TOX3rs4784227C/T0.24(101)Overall1.23 (1.2–1.25)7 × 10−886.8 × 10−201
10q26.13(12)FGFR2rs2981578T/C0.47(102)Overall1.23 (1.21–1.25)1 × 10−1141.3 × 10−245
10q26.13(12)FGFR2rs35054928G/GC0.4(102)Overall1.27 (1.25–1.3)3.5 × 10−1542.3 × 10−322
10q26.13(12)FGFR2rs45631563A/T0.05(102)Overall0.81 (0.78–0.85)9.1 × 10−217.3 × 10−37
2q35(46)IGFBP5rs4442975G/T0.5(103)ER+0.89 (0.87–0.9)3.6 × 10−401.1 × 10−95
2q35(46)IGFBP5rs34005590C/A0.05(104)Overall0.82 (0.79–0.86)1.6 × 10−193.2 × 10−41
5p12(13)FGF10/MRPS30rs10941679A/G0.25(13)ER+1.15 (1.13–1.18)6.2 × 10−435.6 × 10−73
3p24.1(16)SLC4A7rs4973768C/T0.47(16)Overall1.11 (1.09–1.13)1.7 × 10−284.8 × 10−57
17q22(16)rs2787486A/C0.3(105)Overall0.93 (0.91–0.94)1.2 × 10−145.6 × 10−29
22q12.1(106)CHEK2rs17879961A/G0.01(22)Overall1.26 (1.11–1.42)2.4 × 10−049.7 × 10−09
1p11.2(107)EMBP1rs11249433A/G0.41(107)Overall1.11 (1.09–1.13)2.2 × 10−311.8 × 10−52
14q24.1(107)RAD51Brs999737C/T0.23(107)Overall0.91 (0.89–0.93)1.1 × 10−186.5 × 10−39
19p13.11(40)rs67397200C/G0.3(108)BRCA11.03 (1.01–1.05)4.2 × 10−031.6 × 10−08
9p21.3(20)CDKN2A/CDKN2Brs1011970G/T0.16(20)Overall1.07 (1.04–1.09)1.4 × 10−071 × 10−15
10p15.1(20)ANKRD16rs2380205C/T0.44(20)Overall0.98 (0.96–0.99)1.1 × 10−021.7 × 10−04
10q22.3(20)ZMZ1rs704010C/T0.38(20)Overall1.07 (1.05–1.09)1.1 × 10−141.7 × 10−35
11q13.3(20)CCND1rs554219C/G0.13(97)ER+1.21 (1.18–1.24)5.8 × 10−475.8 × 10−47
11q13.3(20)CCND1rs75915166C/A0.06(97)ER+1.28 (1.24–1.33)4.1 × 10−424.1 × 10−95
6q25(20)ESR1rs3757322T/G0.32(93)ER-1.08 (1.06–1.1)1.1 × 10−163.3 × 10−41
6q25(20)ESR1rs9397437G/A0.07(93)ER-1.17 (1.14–1.21)6.3 × 10−214.8 × 10−54
6q25(20)ESR1rs2747652C/T0.48(93)ER-0.94 (0.92–0.960)1.2 × 10−111.3 × 10−26
10q21.2(109)ZNF365rs10995201A/G0.16(110)Overall0.9 (0.88–0.92)4.7 × 10−171.6 × 10−51
9q31.2(21)rs10816625A/G0.06(111)Overall1.11 (1.07–1.15)2.3 × 10−085 × 10−18
9q31.2(21)rs13294895C/T0.18(111)Overall1.06 (1.03–1.08)1.9 × 10−066.5 × 10−17
9q31.2(21)rs676256T/C0.38(111)Overall0.91 (0.9–0.93)1.9 × 10−213.5 × 10−53
5p15.33(47)TERTrs10069690C/T0.26(47)ER-1.06 (1.04–1.08)2.5 × 10−087.8 × 10−17
12q24.21(19)TBX3rs1292011A/G0.42(19)Overall0.92 (0.9–0.94)2.4 × 10−194.4 × 10−39
21q21.1(19)NRIP1rs2823093G/A0.27(19)Overall0.94 (0.92–0.96)1.1 × 10−091.5 × 10−20
6q25.1(112)TAB2rs9485372G/A0.19(112)Overall0.96 (0.93–0.98)7.7 × 10−053.5 × 10−06
6q14.1(113)rs17529111T/C0.22(113)ER-1.02 (1–1.04)4.2 × 10−021.3 × 10−09
20q11.22(113)RALYrs2284378C/T0.32(113)Overall1 (0.98–1.02)7.9 × 10−013.2 × 10−02
5p15.33(92)TERTrs3215401A/AG0.31(92)Overall0.93 (0.91–0.95)7.1 × 10−131.1 × 10−20
1q32.1(48)LGR6rs6678914G/A0.41(48)Overall1 (0.99–1.02)7.3 × 10−013 × 10−01
1q32.1(48)MDM4rs4245739A/C0.26(48)Overall1.02 (1–1.04)2.5 × 10−021.3 × 10−04
2p24.1(48)rs12710696C/T0.37(48)Overall1.03 (1.01–1.04)6.6 × 10−031.3 × 10−08
16q12.2(48)FTOrs11075995T/A0.24(48)Overall1.03 (1.01–1.06)1.3 × 10−038.7 × 10−09
6p24.3(114)TFAP2Ars9348512C/A0.33(114)BRCA21 (0.99–1.02)6.4 × 10−018 × 10−01
22q13.1(60)APOBEC3A/APOBEC3Bchr22:39359355I/D70.1(60)Overall1.1 (1.07–1.14)6.1 × 10−094.9 × 10−12
1p36.22(22)PEX14rs616488A/G0.33(22)Overall0.94 (0.93–0.96)1.8 × 10−095 × 10−20
1p13.2(22)DCLRE1Brs11552449C/T0.17(22)Overall1.04 (1.01–1.06)2.3 × 10−034.6 × 10−11
2q14.1(22)rs4849887C/T0.1(22)Overall0.91 (0.88–0.94)1.2 × 10−106.9 × 10−20
2q31.1(22)DLX2-AS1rs2016394G/A0.47(22)Overall0.95 (0.94–0.97)3.1 × 10−076.2 × 10−12
2q31.1(22)CDCA7rs1550623A/G0.15(22)Overall0.95 (0.93–0.98)8.8 × 10−055.4 × 10−10
2q35(22)DIRC3rs16857609C/T0.26(22)Overall1.06 (1.04–1.09)1.4 × 10−091.8 × 10−25
3p26.1(22)EGPT/ITPR1rs6762644A/G0.38(22)Overall1.05 (1.03–1.07)1.6 × 10−084 × 10−18
3p24.1(22)TGFBR2rs12493607G/C0.34(22)Overall1.05 (1.03–1.07)4.9 × 10−076.9 × 10−14
4q24(22)TET2rs9790517C/T0.23(22)Overall1.04 (1.01–1.06)1.1 × 10−035 × 10−11
4q34.1(22)ADAM29rs6828523C/A0.12(22)Overall0.91 (0.88–0.93)1.2 × 10−111.8 × 10−25
5q11.2(22)RAB3Crs10472076T/C0.38(22)Overall1.03 (1.01–1.04)6.6 × 10−039.6 × 10−09
5q11.2(22)PDE4Drs1353747T/G0.09(22)Overall0.96 (0.93–0.99)7.6 × 10−034.1 × 10−09
5q33.3(22)EBF1rs1432679T/C0.43(22)Overall1.08 (1.06–1.1)2.9 × 10−176.6 × 10−31
6p25.3(22)FOXQ1rs11242675T/C0.37(22)Overall1 (0.98–1.02)9.7 × 10−011 × 10−04
6p23(22)RANBP9rs204247A/G0.44(22)Overall1.04 (1.02–1.06)6.4 × 10−057.9 × 10−13
7q35(22)NOBOX/ARHGEF6rs720475G/A0.25(22)Overall0.96 (0.94–0.98)3 × 10−041.2 × 10−11
8p12(22)rs9693444C/A0.32(22)Overall1.06 (1.04–1.08)1.7 × 10−101.6 × 10−21
8q21.11(22)rs6472903T/G0.17(22)Overall0.94 (0.92–0.96)4.4 × 10−214.4 × 10−21
8q21.11(22)HNF4Grs2943559A/G0.08(22)Overall1.1 (1.07–1.14)4.2 × 10−094 × 10−24
8q24.21(22)MYCrs11780156C/T0.17(22)Overall1.05 (1.03–1.08)2.5 × 10−051.1 × 10−13
9q31.2(22)rs10759243C/A0.29(22)Overall1.06 (1.04–1.08)4.2 × 10−102.2 × 10−18
10p12.31(22)DNAJC1rs7072776G/A0.29(22)Overall1.05 (1.03–1.07)2.7 × 10−071.8 × 10−19
10p12.31(22)DNAJC1rs11814448A/C0.02(22)Overall1.12 (1.06–1.19)1.4 × 10−066.1 × 10−18
10q25.2(22)TCFL2rs7904519A/G0.46(22)Overall1.03 (1.01–1.05)8.6 × 10−041.5 × 10−13
10q26.12(22)rs11199914C/T0.32(22)Overall0.96 (0.94–0.98)2.1 × 10−056.5 × 10−12
11q13.1(22)rs3903072G/T0.47(22)Overall0.97 (0.95–0.97)9.1 × 10−042.3 × 10−12
11q24.3(22)rs11820646C/T0.4(22)Overall0.96 (0.94–0.98)2.5 × 10−052.1 × 10−14
12p13.1(22)rs12422552G/C0.26(22)Overall1.06 (1.04–1.08)3.2 × 10−083.6 × 10−15
12q22(22)NTN4rs17356907A/G0.3(22)Overall0.91 (0.9–0.93)6.6 × 10−201 × 10−39
13q13.1(22)BRCA2rs11571833A/T0.01(22)Overall1.35 (1.23–1.48)4 × 10−103.1 × 10−15
14q13.3(22)PAX9rs2236007G/A0.21(22)Overall0.93 (0.91–0.95)5.8 × 10−104.2 × 10−21
14q24.1(22)RAD51Brs2588809C/T0.17(22)Overall1.06 (1.03–1.08)2.6 × 10−066.3 × 10−14
14q32.11(22)CCDC88Crs941764A/G0.35(22)Overall1.03 (1.02–1.05)3.6 × 10−048.2 × 10−13
16q12.2(22)FTOrs17817449T/G0.41(22)Overall0.95 (0.93–0.96)4.9 × 10−092.5 × 10−21
16q23.2(22)CDYL2rs13329835A/G0.23(22)Overall1.07 (1.05–1.09)8.3 × 10−118.8 × 10−27
18q11.2(22)rs527616G/C0.38(22)Overall0.97 (0.95–0.98)2.8 × 10−046.7 × 10−15
18q11.2(22)CHST9rs1436904T/G0.4(22)Overall0.95 (0.94–0.97)1.1 × 10−079.9 × 10−15
19p13.11(22)ELLrs4808801A/G0.34(22)Overall0.93 (0.91–0.95)2 × 10−124.7 × 10−28
19q13.31(22)KCCN4/LYPD5rs3760982G/A0.46(22)Overall1.05 (1.03–1.07)2.1 × 10−081.4 × 10−16
22q12.2(22)EM1D1rs132390T/C0.04(22)Overall1.04 (0.99–1.09)8.1 × 10−021.2 × 10−08
22q13.1(22)MKL1rs6001930T/C0.1(22)Overall1.12 (1.09–1.16)5.7 × 10−164.4 × 10−34
1q32.1(72)ZC3H11Ars4951011A/G0.16(72)Overall1.04 (1.02–1.07)5.4 × 10−041.3 × 10−05
5q14.3(72)ARRDC3rs10474352C/T0.16(72)Overall0.94 (0.92–0.97)4.5 × 10−114.5 × 10−11
15q26.1(72)PRC1rs2290203G/A0.21(72)Overall0.94 (0.92–0.96)1.8 × 10−078.07 × 10−10
3p14.1(115)ATNX7rs1053338A/G0.14(115)Overall1.05 (1.02–1.07)5 × 10−045.3 × 10−11
7q21.2(115)AKAP9rs6964587G/T0.39(115)Overall1.03 (1.02–1.05)2.2 × 10−049 × 10−11
7q34(116)rs11977670G/A0.43(116)Lobular1.06 (1.04–1.08)1.9 × 10−111 × 10−16
1q21.1(23)RNF115rs12405132C/T0.37(23)Overall0.97 (0.95–0.99)1 × 10−036.3 × 10−10
1q21.2(23)OTUD7Brs12048493A/C0.38(23)Overall1.04 (1.02–1.06)9.4 × 10−068.6 × 10−14
1q43(23)EXO1rs72755295A/G0.03(23)Overall1.15 (1.09–1.2)8 × 10−081.7 × 10−14
3p21.31(23)rs6796502G/A0.1(23)Overall0.92 (0.89–0.95)2.5 × 10−085.5 × 10−15
5p15.1(23)rs13162653G/T0.45(23)Overall0.99 (0.97–1.010)1.8 × 10−015.4 × 10−07
5p13.3(23)rs2012709C/T0.48(23)Overall1.02 (1–1.04)2.1 × 10−021.2 × 10−08
5q14.2(23)ATG10rs7707921A/T0.25(23)Overall0.96 (0.94–0.98)1.2 × 10−041.7 × 10−12
6p22.1(23)rs9257408G/C0.41(23)Overall1.02 (1–1.040)5.5 × 10−026.9 × 10−08
7q32.3(23)FLJ43663rs4593472C/T0.35(23)Overall0.97 (0.95–0.99)7.9 × 10-041.8 × 10−11
8p11.23(23)rs13365225A/G0.18(23)Overall0.91 (0.89–0.93)1.2 × 10-151.4 × 10−20
8q23.3(23)LINC00536rs13267382G/A0.36(23)Overall1.03 (1.01–1.05)8.7 × 10−041.6 × 10−11
14q32.12(23)RIN3rs11627032T/C0.25(23)Overall0.96 (0.94–0.98)1.6 × 10−044.1 × 10−11
17q11.2(23)ATAD5rs146699004GGT/G0.27(23)Overall0.97 (0.95–0.99)1.3 × 10−032 × 10−09
17q25.3(23)rs745570G/A0.5(23)Overall1.03 (1.01–1.05)2.1 × 10−033.9 × 10−10
18q12.3(23)SETBP1rs6507583A/G0.07(23)Overall0.92 (0.89–0.96)9.5 × 10−062.2 × 10−12
2p23.2(10)WDR43rs4577244C/T0.23(10)ER-/BRCA11.01 (0.99–1.03)2.4 × 10−014.3 × 10−01
12p11.22(10)rs7297051C/T0.24(10)ER-/BRCA10.89 (0.87–0.91)2.9 × 10−273 × 10−60
13q22.1(10)rs6562760G/A0.24(10)ER-/BRCA10.95 (0.93–0.97)8.6 × 10−061.5 × 10−09
1p36.13(24)KLHDC7Ars2992756C/T0.49(24)Overall1.06 (1.04–1.08)1.3 × 10−111.6 × 10−15
1p34.2(24)rs4233486T/C0.36(24)Overall0.97 (0.95–0.98)2.3 × 10−049.1 × 10−09
1p34.2(24)HIVEP3rs79724016T/G0.03(24)Overall0.93 (0.88–0.97)3.3 × 10−033.5 × 10−08
1p34.1(24)PIK3R3, LOC101929626rs1707302G/A0.34(24)Overall0.96 (0.95–0.98)1.4 × 10−043.0 × 10−08
1p32.3(24)rs140850326I/D90.49(24)Overall0.97 (0.95–0.99)3.4 × 10−043.9 × 10−08
1p22.3(24)rs17426269G/A0.15(24)Overall1.05 (1.02–1.07)1.7 × 10−041.7 × 10−08
1p12(24)rs7529522T/C0.23(24)Overall1.06 (1.04–1.08)1.6 × 10−081.7 × 10−10
1q22(24)TRIM46rs4971059G/A0.35(24)Overall1.05 (1.03–1.07)3.9 × 10−084.8 × 10−11
1q32.1(24)PHLDA3rs35383942C/T0.06(24)Overall1.12 (1.08–1.17)12 × 10−093.8 × 10−13
1q41(24)ESRRGrs11117758G/A0.21(24)Overall0.95 (0.93–0.97)7.7 × 10−073.9 × 10−09
2p25.1(24)GRHL1rs113577745C/G0.1(24)Overall1.08 (1.05–1.11)3.7 × 10−073.9 × 10−10
2p23.3(24)ADCY3rs6725517A/G0.41(24)Overall0.96 (0.94–0.98)7.5 × 10−062.9 × 10−12
2q13(24)BCL2L11rs71801447CTTATGTT/C0.06(24)Overall1.09 (1.05–1.13)7.7 × 10−063.7 × 10−08
2q36.3(24)rs12479355A/G0.21(24)Overall0.96 (0.94–0.98)4.7 × 10−042.4 × 10−08
3p13(24)FOXP1rs6805189T/C0.48(24)Overall0.97 (0.95–0.99)3.3 × 10−044.6 × 10−08
3p12.1(24)VGLL3rs13066793A/G0.09(24)Overall0.94 (0.91–0.97)1.5 × 10−041.0 × 10−09
3p12.1(24)CMSS1, FILIP1Lrs9833888G/T0.22(24)Overall1.06 (1.04–1.08)2.6 × 10−075.2 × 10−10
3q23(24)ZBTB38rs34207738CTT/C0.41(24)Overall1.06 (1.04–1.08)1.4 × 10−093.2 × 10−15
3q26.31(24)rs58058861G/A0.21(24)Overall1.06 (1.04–1.09)1.6 × 10−081.9 × 10−10
4p14(24)rs6815814A/C0.26(24)Overall1.06 (1.04–1.08)6.1 × 10−086.1 × 10−13
4q21.23(24)HELQ4:84370124TA/TAA0.47(24)Overall1.04 (1.02–1.05)1.7 × 10−042.2 × 10−09
4q22.1(24)LOC105369192rs10022462C/T0.44(24)Overall1.04 (1.02–1.06)9.4 × 10−061.6 × 10−09
4q28.1(24)rs77528541G/T0.13(24)Overall0.95 (0.92–0.97)4.8 × 10−051.4 × 10−09
5p15.33(24)AHRRrs116095464T/C0.05(24)Overall1.06 (1.02–1.1)2.6 × 10−033.8 × 10−09
5q11.1(24)rs72749841T/C0.16(24)Overall0.93 (0.91–0.96)8.5 × 10−067.2 × 10−10
5q11.1(24)rs35951924A/AT0.32(24)Overall0.95 (0.93–0.97)4.0 × 10−071.3 × 10−11
5q22.1(24)NREPrs6882649T/G0.34(24)Overall0.97 (0.95–0.99)2.7 × 10−033.7 × 10−09
5q31.1(24)HSPA4rs6596100C/T0.25(24)Overall0.94 (0.92–0.96)5.2 × 10−087.7 × 10−09
5q35.1(24)rs4562056G/T0.33(24)Overall1.05 (1.03–1.07)4.1 × 10−074.7 × 10−10
6p22.3(24)ATXN1rs3819405C/T0.33(24)Overall0.96 (0.94–0.97)2.2 × 10−061.7 × 10−08
6p22.3(24)CDKAL1rs2223621C/T0.38(24)Overall1.04 (1.02–1.06)1.0 × 10−043.0 × 10−10
6p22.2(24)rs71557345G/A0.07(24)Overall0.92 (0.88–0.96)8.4 × 10−053.9 × 10−10
6q14.1(24)rs12207986A/G0.47(24)Overall0.97 (0.95–0.98)2.0 × 10−041.5 × 10−09
6q23.1(24)L3MBTL3rs6569648T/C0.24(24)Overall0.94 (0.92–0.96)4.8 × 10−083.0 × 10−12
7p15.3(24)DNAH11, CDCA7Lrs7971A/G0.35(24)Overall0.96 (0.94–0.98)1.4 × 10−051.9 × 10−08
7p15.1(24)CREB5rs17156577T/C0.11(24)Overall1.05 (1.02–1.08)3.8 × 10−044.3 × 10−09
7q21.3(24)rs17268829T/C0.28(24)Overall1.05 (1.03–1.07)1.3 × 10−064.5 × 10−13
7q22.1(24)CUX1rs71559437G/A0.12(24)Overall0.93 (0.91–0.96)9.1 × 10−075.1 × 10−12
8q22.3(24)rs514192T/A0.32(24)Overall1.05 (1.03–1.07)3.7 × 10−065.6 × 10−09
8q23.1(24)ZFPM3rs12546444A/T0.1(24)Overall0.93 (0.91–0.96)5.8 × 10−067.5 × 10−11
8q24.13(24)rs58847541G/A0.15(24)Overall1.08 (1.05–1.1)7.3 × 10−095.5 × 10−13
9q33.1(24)ASTN2rs1895062A/G0.41(24)Overall0.94 (0.92–0.95)6.9 × 10−131.1 × 10−14
9q33.3(24)LMX1Brs10760444A/G0.43(24)Overall1.03 (1.02–1.05)2.8 × 10−049.1 × 10−09
9q34.2(24)ABOrs8176636I/D100.2(24)Overall1.03 (1.01–1.06)3.2 × 10−031.4 × 10−08
10p14(24)rs67958007TG/T0.12(24)Overall1.09 (1.06–1.12)1.8 × 10−091.7 × 10−10
10q23.33(24)rs140936696C/CAA0.18(24)Overall1.04 (1.02–1.07)7.4 × 10−044.2 × 10−08
11p15(24)PIDD1rs6597981G/A0.48(24)Overall0.96 (0.94–0.97)5.7 × 10−071.4 × 10−12
12q21.31(24)rs202049448T/C0.34(24)Overall0.95 (0.93–0.97)2.5 × 10−072.7 × 10−08
12q24.31(24)rs206966C/T0.16(24)Overall1.05 (1.02–1.07)2.7 × 10−043.8 × 10−08
14q32.33(24)ADSSL1rs10623258C/CTT0.45(24)Overall1.04 (1.02–1.06)2.7 × 10−052.3 × 10−08
16q12.2(24)rs28539243G/A0.49(24)Overall1.05 (1.03–1.07)3.6 × 10−089.1 × 10−15
16q13(24)AMFRrs2432539G/A0.4(24)Overall1.03 (1.02–1.05)3.1 × 10−044.0 × 10−08
16q24.2(24)rs4496150C/A0.25(24)Overall0.96 (0.94–0.98)3.4 × 10−058.1 × 10−09
17q21.2(24)CNTNAP1rs72826962C/T0.01(24)Overall1.2 (1.11–1.3)5.1 × 10−064.6 × 10−09
17q21.31(24)KANSL1rs2532263G/A0.19(24)Overall0.95 (0.93–0.97)4.7 × 10−066.9 × 10−13
18q12.1(24)GAREM1rs117618124T/C0.05(24)Overall0.89 (0.85–0.92)4.5 × 10−085.5 × 10−12
19p13.13(24)NFIX1rs78269692T/C0.05(24)Overall1.09 (1.04–1.13)3.9 × 10−051.9 × 10−09
19p13.12(24)rs2594714G/A0.23(24)Overall0.97 (0.95–0.99)6.7 × 10−031.1 × 10−08
19p13.11(24)GATAD2A, MIR640rs2965183G/A0.35(24)Overall1.04 (1.02–1.06)9.6 × 10−066.3 × 10−12
19q13.22(24)GIPRrs71338792A/AT0.23(24)Overall1.05 (1.03–1.07)8.1 × 10−063.5 × 10−09
20p12.3(24)MCM8rs16991615G/A0.06(24)Overall1.1 (1.06–1.14)1.4 × 10−071.9 × 10−09
20q13.13(24)rs6122906A/G0.18(24)Overall1.05 (1.03–1.07)2.9 × 10−052.5 × 10−10
22q13.1(24)PLA2G6rs738321C/G0.38(24)Overall0.95 (0.93–0.97)2.7 × 10−081.0 × 10−13
22q13.2(24)XRCC6rs73161324C/T0.06(24)Overall1.06 (1.02–1.09)3.8 × 10−032.0 × 10−09
22q13.31(24)rs28512361G/A0.11(24)Overall1.05 (1.02–1.08)5.7 × 10−042.3 × 10−08
  • aRisk locus was originally discovered in the associated reference.

  • bMAF reported in OncoArray controls.

  • cReference for the refined SNP of interest.

  • dBreast cancer subtype in which the refined SNP was evaluated.

  • eORs reported for overall breast cancer OncoArray analysis.

  • f95% confidence interval (CI) reported for overall breast cancer OncoArray analysis.

  • gP values reported for overall breast cancer OncoArray analysis.

  • hCombined meta-analysis P values reported for overall breast cancer.