Table 4.

Pleiotropic cancer risk loci shared between EOC and breast and/or prostate cancers identified at P < 10−8 specifically by cross-cancer type meta-analysis in European ancestry populations (ref. 40)a

LocusLead SNPEffect allele, EAFCancer typeOR (95% CI)P
Associations with ovarian, breast, and prostate cancer risk with the same direction of effect
2q13rs17041869ABreast cancer0.97 (0.94–0.99)7.1 × 10−3
0.88Ovarian cancerb0.93 (0.88–0.97)5.3 × 10−4
Prostate cancer0.92 (0.89–0.95)2.6 × 10−6
Meta-analysis0.94 (0.93–0.96)5.1 × 10−9
11q12.3rs7937840TBreast cancer1.04 (1.02–1.06)3.6 × 10−5
0.26Ovarian cancer1.05 (1.01–1.09)5.8 × 10−3
Prostate cancer1.05 (1.02–1.08)8.9 × 10−4
Meta-analysis1.05 (1.03–1.06)5.0 × 10−9
19p13.11rs1469713ABreast cancer0.95 (0.94–0.97)9.9 × 10−8
0.64Ovarian cancer0.96 (0.93–0.99)6.3 × 10−3
Prostate cancer0.97 (0.94–0.99)1.0 × 10−2
Meta-analysis0.96 (0.95–0.97)3.4 × 10−10
Associations with ovarian and breast cancer risk with the same direction of effect
9q31.1rs200182588GBreast cancer0.96 (0.94–0.98)1.9 × 10−5
0.56Ovarian cancer0.93 (0.89–0.96)2.8 × 10−6
Meta-analysis0.95 (0.94–0.97)8.9 × 10−9
15q26.1rs8037137TBreast cancer1.07 (1.04–1.10)1.8 × 10−7
0.86Ovarian cancer1.09 (1.04–1.14)2.1 × 10−4
Meta-analysis1.07 (1.05–1.10)9.1 × 10−10
  • Abbreviations: EAF, effect allele frequency; ref., reference.

  • aThis meta-analysis did not include data from the OncoArray project (ref. 23).

  • bOvarian cancer refers to all invasive EOCs.