Pleiotropic cancer risk loci shared between EOC and breast and/or prostate cancers identified at P < 10−8 specifically by cross-cancer type meta-analysis in European ancestry populations (ref. 40)a
| Locus | Lead SNP | Effect allele, EAF | Cancer type | OR (95% CI) | P |
|---|---|---|---|---|---|
| Associations with ovarian, breast, and prostate cancer risk with the same direction of effect | |||||
| 2q13 | rs17041869 | A | Breast cancer | 0.97 (0.94–0.99) | 7.1 × 10−3 |
| 0.88 | Ovarian cancerb | 0.93 (0.88–0.97) | 5.3 × 10−4 | ||
| Prostate cancer | 0.92 (0.89–0.95) | 2.6 × 10−6 | |||
| Meta-analysis | 0.94 (0.93–0.96) | 5.1 × 10−9 | |||
| 11q12.3 | rs7937840 | T | Breast cancer | 1.04 (1.02–1.06) | 3.6 × 10−5 |
| 0.26 | Ovarian cancer | 1.05 (1.01–1.09) | 5.8 × 10−3 | ||
| Prostate cancer | 1.05 (1.02–1.08) | 8.9 × 10−4 | |||
| Meta-analysis | 1.05 (1.03–1.06) | 5.0 × 10−9 | |||
| 19p13.11 | rs1469713 | A | Breast cancer | 0.95 (0.94–0.97) | 9.9 × 10−8 |
| 0.64 | Ovarian cancer | 0.96 (0.93–0.99) | 6.3 × 10−3 | ||
| Prostate cancer | 0.97 (0.94–0.99) | 1.0 × 10−2 | |||
| Meta-analysis | 0.96 (0.95–0.97) | 3.4 × 10−10 | |||
| Associations with ovarian and breast cancer risk with the same direction of effect | |||||
| 9q31.1 | rs200182588 | G | Breast cancer | 0.96 (0.94–0.98) | 1.9 × 10−5 |
| 0.56 | Ovarian cancer | 0.93 (0.89–0.96) | 2.8 × 10−6 | ||
| Meta-analysis | 0.95 (0.94–0.97) | 8.9 × 10−9 | |||
| 15q26.1 | rs8037137 | T | Breast cancer | 1.07 (1.04–1.10) | 1.8 × 10−7 |
| 0.86 | Ovarian cancer | 1.09 (1.04–1.14) | 2.1 × 10−4 | ||
| Meta-analysis | 1.07 (1.05–1.10) | 9.1 × 10−10 | |||