Table 1.

New EOC risk loci identified by the OncoArray meta-analysis at P < 5 × 10−8 (ref. 23)a

LocusLead SNPPhenotypeEffect alleleEAFOR (95% CI)P
3q22.3rs112071820MucinousGCCAG0.281.29 (1.20–1.37)1.5E−13
3q28rs9870207S. borderline + LGSOCA0.691.19 (1.12–1.27)4.5E−08
4q32.3rs13113999S. borderlineT0.521.23 (1.14–1.32)4.7E−08
5q12.3rs555025179EndometrioidGACAC0.531.18 (1.11–1.26)4.5E−08
8q21.11rs150293538S. borderline + LGSOCT0.982.19 (1.65–2.90)2.0E−09
9q31.1rs320203bMucinousA0.851.29 (1.18–1.41)1.7E−08
10q24.33rs7902587S. borderline + LGSOCT0.101.29 (1.18–1.41)4.0E−08
18q11.2rs8098244S. borderline + LGSOCA0.281.19 (1.12–1.27)3.9E−08
22q12.1rs6005807HGSOCC0.901.17 (1.10–1.23)1.2E−08
2q13rs2165109HGSOCC0.251.09 (1.05–1.12)2.0E−08
8q24.21rs9886651HGSOCG0.461.08 (1.05–1.11)1.9E−09
12q24.31rs7953249HGSOCG0.421.08 (1.06–1.11)4.5E−10
  • Abbreviations: EAF, effect allele frequency; S. borderline, serous borderline.

  • aIn European ancestry populations.

  • bAll risk loci listed except rs320203 had BFDP <10%.