Table 6.

Statistically significant effect modification of genotypes between diagnostic radiation exposure and risk of thyroid microcarcinoma (n = 672)

NonexposedExposed
ChromosomeGene nameGenotypeCasesControlsORa (95% CI)CasesControlsORa (95% CI)
7XRCC2_01rs10234749
 CC3361.001352517.82 (2.20–27.78)
 AC or AA6161.00601620.65 (0.20–2.11)
Pinteraction0.0041
10MGMT_33rs10829618
 GG3411.001222647.16 (2.02–25.39)
 GC or CC6111.00751490.99 (0.32–3.12)
Pinteraction0.036
10MGMT_39rs4751112
 AA3391.001182566.78 (1.89–24.30)
 AG or GG7131.00791571.01 (0.34–2.99)
Pinteraction0.045
11ALKBH3_01rs12804822
 AA2331.001092328.92 (1.96–40.55)
 AC or CC7191.00881811.23 (0.44–3.46)
Pinteraction0.022
11ALKBH3_07rs3740983
 TT2321.001042249.52 (2.07–43.81)
 TG or GG7201.00931891.29 (0.47–3.53)
Pinteraction0.030
11ALKBH3_08rs7482199
 TT2341.001032318.97 (1.97–40.92)
 TC or CC8181.00941821.15 (0.43–3.07)
Pinteraction0.018
11ALKBH3_11rs11037726
 AA2341.001062339.01 (1.97–41.15)
 TA or TT8181.00911791.17 (0.44–3.15)
Pinteraction0.017
13PARP4_04rs4770687
 GG6131.00481210.62 (0.18–2.16)
 AG or AA4391.001482915.73 (1.89–17.40)
Pinteraction0.020
13ERCC5_07rs4150355
 GG7221.00771731.35 (0.49–3.69)
 AG or AA2301.001202408.01 (1.72–37.23)
Pinteraction0.033
13ERCC5_11rs17655
 GG9291.001022440.95 (0.39–2.35)
 CG or CC1231.009516921.97 (2.74–176.47)
Pinteraction0.030
13ERCC5_13rs9586002
 GG2311.001202438.88 (1.96–40.16)
 TG or TT7211.00771701.11 (0.40–3.10)
Pinteraction0.033
13ERCC5_14rs1886087
 AA6161.00521111.47 (0.47–4.62)
 TA or TT3361.001453025.77 (1.62–20.54)
Pinteraction0.036
  • aAdjusted for age (continuous), gender, race, and BMI.