Table 4.

Statistically significant effect modification of genotypes between diagnostic radiation exposure and risk of thyroid cancer (n = 905)

NonexposedExposed
ChromosomeGene nameGenotypeCasesControlsORa (95% CI)CasesControlsORa (95% CI)
3TOPBP1_06rs17301766
 CC21401.002692601.96 (1.06–3.66)
 TC or TT15121.001341520.81 (0.33–1.98)
Pinteraction0.028
3TOPBP1_09rs11706586
 CC20401.002672622.06 (1.10–3.86)
 TC or TT15121.001351510.85 (0.35–2.08)
Pinteraction0.025
3TOPBP1_10rs7349558
 AA22401.002702571.94 (1.05–3.59)
 AC or CC14121.001331560.79 (0.32–1.95)
Pinteraction0.039
7RPA3_01rs4720751
 TT20241.001752170.85 (0.43–1.71)
 TC or CC15281.002271962.91 (1.39–6.09)
Pinteraction0.034
7RPA3_02rs17136898
 AA22411.003012922.11 (1.15–3.88)
 AG or GG13111.001011210.78 (0.29–2.07)
Pinteraction0.050
7XRCC2_01rs10234749
 CC19361.002792512.51 (1.32–4.75)
 AC or AA16161.001221620.59 (0.25–1.44)
Pinteraction0.025
10MGMT_02rs1762444
 GG8251.001581613.36 (1.37–8.27)
 AG or AA27271.002442520.98 (0.52–1.85)
Pinteraction0.024
10MGMT_32rs12219606
 CC8211.001391432.55 (0.98–6.65)
 AC or AA27311.002652701.19 (0.65–2.16)
Pinteraction0.049
10MGMT_36rs4750763
 AA7261.001651713.79 (1.44–9.98)
 AC or CC28261.002372420.99 (0.54–1.85)
Pinteraction0.015
11ALKBH3_03rs11037690
 GG14321.002031932.43 (1.15–5.14)
 AG or AA21201.001982200.99 (0.48–2.02)
Pinteraction0.029
11ALKBH3_14rs10768994
 TT8261.001371312.88 (1.13–7.29)
 TC or CC28261.002672820.99 (0.53–1.84)
Pinteraction0.0086
11ALKBH3_15rs10768995
 GG21191.001461580.97 (0.45–2.09)
 GC or CC14331.002562552.37 (1.16–4.86)
Pinteraction0.012
11ALKBH3_19rs868784
 CC11291.001691552.66 (1.16–6.12)
 TC or TT24231.002332581.06 (0.54–2.05)
Pinteraction0.018
11ALKBH3_20rs3893853
 CC20381.002752472.01 (1.06–3.82)
 TC or TT16141.001281660.85 (0.36–1.98)
Pinteraction0.014
11ALKBH3_21rs4755217
 TT8261.001371332.86 (1.13–7.24)
 TC or CC27251.002592751.03 (0.55–1.95)
Pinteraction0.014
11ALKBH3_22rs1973717
 CC20201.001551651.10 (0.52–2.34)
 TC or TT15321.002452472.09 (1.03–4.26)
Pinteraction0.045
13PARP4_04rs4770687
 GG14131.00991210.62 (0.23–1.65)
 AG or AA22391.003032912.28 (1.24–4.19)
Pinteraction0.043
19LIG1_01rs251693
 TT16181.001121380.71 (0.32–1.61)
 TC or CC19341.002912752.51 (1.30–4.83)
Pinteraction0.024
19LIG1_02rs2288878
 GG16181.001081370.72 (0.32–1.61)
 AG or AA20341.002942762.36 (1.23–4.50)
Pinteraction0.024
19LIG1_03rs274897
 CC16181.001091380.69 (0.30–1.55)
 GC or GG19341.002932742.55 (1.32–4.91)
Pinteraction0.020
19LIG1_04rs2386523
 CC14151.00861030.73 (0.30–1.80)
 TC or TT21371.003173092.34 (1.25–4.38)
Pinteraction0.025
19LIG1_05rs2163619
 GG13131.0073950.57 (0.22–1.50)
 AG or AA22391.003303162.40 (1.30–4.42)
Pinteraction0.0060
19LIG1_07rs274873
 AA14161.00951110.59 (0.24–1.46)
 AG or GG22361.003083022.24 (1.21–4.15)
Pinteraction0.035
19LIG1_10rs10421339
 GG15151.00941130.45 (0.18–1.16)
 GC or CC20371.003083002.50 (1.34–4.69)
Pinteraction0.0081
XUBE2A_01rs5910616
 GG33431.003093281.28 (0.75–2.19)
 AG or GG291.0091856.82 (1.08–43.08)
Pinteraction0.043
  • aAdjusted for age (continuous), gender, race, and BMI.