Table 3.

Age-and sex-adjusted and multivariable-adjusted HRs (and 95% CIs) for microscopically confirmed pancreatic cancer according to nut consumption; NLCS, 1986–2006

Median intakeaMenWomenTotal population
Food itemMenWomenPerson-yearsCasesAge-adjusted HR (95% CI)Multivariable-adjusted HRb (95% CI)Person-yearsCasesAge-adjusted HR (95% CI)Multivariable-adjusted HRb (95% CI)Age- and sex-adjusted HR (95% CI)Multivariable-adjusted HRc (95% CI)
Total nuts (g/d)
 00.00.08,888681.00 (reference)1.00 (reference)13,529601.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 0.1–<52.52.19,675620.84 (0.58–1.21)0.86 (0.59–1.24)12,393671.24 (0.86–1.78)1.23 (0.84–1.79)1.02 (0.79–1.32)1.03 (0.79–1.35)
 5–<108.57.83,951180.60 (0.35–1.03)0.56 (0.32–0.99)3,883140.84 (0.46–1.55)0.81 (0.43–1.54)0.71 (0.47–1.06)0.68 (0.45–1.04)
 10+21.415.77,124400.75 (0.50–1.13)0.72 (0.47–1.11)4,280201.08 (0.64–1.82)0.99 (0.56–1.73)0.88 (0.63–1.22)0.85 (0.60–1.19)
Ptrend0.2180.1630.8480.6020.2700.196
 Continuous, per 5 g/d increment0.96 (0.90–1.03)0.95 (0.89–1.03)0.98 (0.88–1.08)0.96 (0.86–1.07)0.96 (0.91–1.02)0.96 (0.90–1.02)
Tree nuts (g/d)
 00.00.021,3941501.00 (reference)1.00 (reference)23,8511161.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 0.1–<51.61.66,704310.66 (0.44–0.99)0.68 (0.45–1.03)8,367411.02 (0.70–1.47)1.00 (0.67–1.49)0.83 (0.63–1.08)0.85 (0.64–1.13)
 5+8.68.91,54270.65 (0.30–1.43)0.68 (0.31–1.50)1,86640.45 (0.16–1.23)0.42 (0.15–1.20)0.56 (0.30–1.04)0.56 (0.30–1.06)
Ptrend0.1690.2140.1160.1050.0430.056
 Continuous, per 5 g/d increment0.91 (0.63–1.31)0.92 (0.64–1.33)0.96 (0.65–1.42)0.95 (0.62–1.44)0.93 (0.70–1.24)0.94 (0.71–1.25)
Peanuts (g/d)
 00.00.09,995721.00 (reference)1.00 (reference)15,938701.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 0.1–<52.52.110,542690.92 (0.65–1.30)0.92 (0.64–1.32)12,639621.14 (0.80–1.64)1.15 (0.80–1.67)1.03 (0.80–1.32)1.04 (0.80–1.35)
 5–<108.58.53,285110.48 (0.25–0.92)0.44 (0.23–0.85)2,556161.49 (0.83–2.65)1.35 (0.73–2.47)0.83 (0.53–1.28)0.77 (0.50–1.21)
 10+21.417.15,816360.89 (0.58–1.36)0.85 (0.55–1.33)2,951131.03 (0.56–1.91)0.98 (0.51–1.88)0.97 (0.68–1.37)0.94 (0.65–1.35)
Ptrend0.5080.4070.6470.8940.7000.550
 Continuous, per 5 g/d increment0.96 (0.90–1.03)0.95 (0.89–1.02)0.98 (0.88–1.08)0.95 (0.85–1.06)0.96 (0.91–1.02)0.95 (0.90–1.01)
Peanut butter (g/d)
 00.00.021,2031421.00 (reference)1.00 (reference)24,8831121.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 0.1-<51.21.25,164351.04 (0.70–1.53)1.05 (0.70–1.57)5,970341.28 (0.86–1.91)1.27 (0.84–1.93)1.14 (0.86–1.51)1.16 (0.87–1.55)
 5+9.66.93,272110.51 (0.27–0.97)0.53 (0.28–1.00)3,232151.04 (0.59–1.83)1.05 (0.58–1.88)0.73 (0.48–1.11)0.73 (0.48–1.12)
Ptrend0.0370.0470.8070.8230.1390.141
 Continuous, per 5 g/d increment0.86 (0.67–1.11)0.87 (0.68–1.12)0.96 (0.77–1.19)0.94 (0.75–1.17)0.90 (0.77–1.07)0.90 (0.76–1.06)
  • aMedian intake in the subcohort.

  • bAdjusted for age (years; continuous); cigarette smoking [status (never/former/current), frequency (n/day; continuous, centered) and duration (years; continuous, centered)]; BMI (kg/m2; continuous); family history of pancreatic cancer (no/yes); history of diabetes (no/yes); educational level (low/medium/high); total energy intake (kcal/d; continuous) and alcohol consumption (g/d; continuous).

  • cAdjusted for b and sex (male/female).