Table 4.

Association between cumulative number of times reported antidepressant use at each cycle and invasive breast cancer risk, NHS (2000–2012), and NHSII (2003–2013)

All invasive casesER positiveER negativePostmenopausal at diagnosis
Cases/person-yearsAge- and calendar year adjustedFully adjustedaCases/person-yearsFully adjustedaCases/person-yearsFully adjustedaCases/person-yearsFully adjusteda
NHS (n= 2,667 cases)
 02,194/666,5011 (ref)1 (ref)1,816/666,5011 (ref)269/666,5011 (ref)2,186/666,4891 (ref)
 1159/52,8260.94 (0.80–1.11)0.93 (0.79–1.10)126/52,8260.90 (0.75–1.09)23/52,8261.01 (0.65–1.58)158/52,8250.93 (0.78–1.10)
 2100/30,8511.03 (0.84–1.26)0.99 (0.80–1.23)77/30,8510.93 (0.73–1.18)15/30,8511.10 (0.63–1.92)100/30,8511.00 (0.81–1.23)
 3+214/71,1791.03 (0.89–1.19)0.97 (0.82–1.15)168/71,1790.91 (0.76–1.10)36/71,1791.26 (0.82–1.94)214/71,1790.98 (0.82–1.16)
NHS II (n= 1,347 cases)
 0905/478,1151 (ref)1 (ref)716/478,1151 (ref)151/478,1151 (ref)524/477,3281 (ref)
 1127/61,7021.09 (0.90–1.31)1.06 (0.87–1.29)103/61,7021.09 (0.87–1.35)21/61,7021.03 (0.63–1.68)78/61,6201.06 (0.83–1.37)
 2109/61,1400.92 (0.75–1.12)0.88 (0.71–1.08)85/61,1400.87 (0.68–1.10)21/61,1400.99 (0.61–1.61)71/61,0610.87 (0.67–1.14)
 3+206/111,1650.94 (0.80–1.09)0.85 (0.69–1.03)177/111,1650.91 (0.73–1.13)24/111,1650.62 (0.36–1.05)145/111,0310.84 (0.66–1.07)
Pooled (n= 4,014 cases)
 03,099/1,144,6161 (ref)1 (ref)2,532/1,144,6161 (ref)420/1,144,6161 (ref)2,710/1,143,8171 (ref)
 1286/113,9881.01 (0.87–1.16)0.98 (0.86–1.12)229/113,9880.98 (0.82–1.18)44/113,9881.02 (0.73–1.42)236/114,4450.97 (0.84–1.11)
 2209/91,9910.97 (0.84–1.12)0.93 (0.80–1.08)162/91,9910.90 (0.76–1.06)36/91,9911.03 (0.72–1.50)171/91,9120.95 (0.80–1.12)
 3+420/182,3440.99 (0.89–1.09)0.92 (0.80–1.05)345/182,3440.91 (0.79–1.05)60/182,3440.90 (0.44–1.81)359/182,2100.93 (0.81–1.07)
  • aAdjusted for age, calendar year, BMI, count of clinical depression, age at menarche, current oral contraceptive use (NHSII only), type of PMH use, age at menopause, age at first birth & parity, history of biopsy-confirmed benign breast disease, family history of breast cancer, mammogram in prior 2 years, smoking status, physical activity, alcohol intake, and AHEI score.