Table 5.

Statistically significant effect modification of genotypes between diagnostic radiation exposure and risk of PTC (n = 838)

NonexposedExposed
ChromosomeGene nameGenotypeCasesControlsORa (95% CI)CasesControlsORa (95% CI)
3TOPBP1_06rs17301766
 CC21401.002212601.62 (0.86–3.06)
 TC or TT14121.001161520.79 (0.32–1.96)
Pinteraction0.044
3TOPBP1_09rs11706586
 CC20401.002212621.73 (0.91–3.27)
 TC or TT14121.001151510.81 (0.33–2.01)
Pinteraction0.035
7RPA3_01rs4720751
 TT19241.001412170.69 (0.33–1.41)
 TC or CC15281.001961962.73 (1.29–5.75)
Pinteraction0.024
7HUS1_03rs3176595
 GG31361.002613281.03 (0.59–1.82)
 AG or AA4161.0074844.20 (1.09–16.23)
Pinteraction0.033
7XRCC2_01rs10234749
 CC18361.002312512.24 (1.16–4.32)
 AC or AA16161.001041620.50 (0.20–1.24)
Pinteraction0.026
10MGMT_02rs1762444
 GG8251.001311612.86 (1.15–7.11)
 AG or AA26271.002052520.84 (0.44–1.62)
Pinteraction0.025
10MGMT_36rs4750763
 AA7261.001371713.49 (1.30–9.39)
 AC or CC27261.001992420.85 (0.45–1.59)
Pinteraction0.016
11ALKBH3_03rs11037690
 GG13321.001711932.16 (0.99–4.72)
 AG or AA21201.001642200.88 (0.43–1.81)
Pinteraction0.026
11ALKBH3_14rs10768994
 TT8261.001151312.40 (0.93–6.17)
 TC or CC27261.002232820.87 (0.46–1.63)
Pinteraction0.010
11ALKBH3_15rs10768995
 GG21191.001241580.83 (0.38–1.80)
 GC or CC13331.002122552.21 (1.05–4.64)
Pinteraction0.011
11ALKBH3_19rs868784
 CC10291.001441552.40 (1.01–5.72)
 TC or TT24231.001932580.92 (0.47–1.80)
Pinteraction0.014
11ALKBH3_20rs3893853
 CC19381.002312471.72 (0.89–3.34)
 TC or TT16141.001061660.74 (0.31–1.74)
Pinteraction0.013
11ALKBH3_21rs4755217
 TT8261.001161332.47 (0.96–6.32)
 TC or CC26251.002142750.90 (0.47–1.72)
Pinteraction0.015
11ALKBH3_22rs1973717
 CC20201.001331650.95 (0.44–2.04)
 TC or TT14321.002012471.89 (0.91–3.96)
Pinteraction0.048
13PARP4_04rs4770687
 GG13131.00801210.56 (0.20–1.55)
 AG or AA22391.002562911.92 (1.04–3.54)
Pinteraction0.042
19LIG1_01rs251693
 TT16181.00931380.55 (0.24–1.28)
 TC or CC18341.002442752.33 (1.19–4.56)
Pinteraction0.019
19LIG1_02rs2288878
 GG16181.00901370.55 (0.24–1.28)
 AG or AA19341.002462762.20 (1.13–4.27)
Pinteraction0.020
19LIG1_03rs274897
 CC16181.00901380.52 (0.22–1.21)
 GC or GG18341.002462742.38 (1.22–4.67)
Pinteraction0.015
19LIG1_04rs2386523
 CC14151.00721030.56 (0.22–1.43)
 TC or TT20371.002653092.16 (1.14–4.10)
Pinteraction0.020
19LIG1_05rs2163619
 GG13131.0061950.39 (0.14–1.12)
 AG or AA21391.002763162.19 (1.17–4.09)
Pinteraction0.0044
19LIG1_07rs274873
 AA14161.00791110.43 (0.16–1.11)
 AG or GG21361.002583022.07 (1.10–3.90)
Pinteraction0.026
19LIG1_10rs10421339
 GG15151.00791130.34 (0.12–0.91)
 GC or CC19371.002573002.29 (1.20–4.36)
Pinteraction0.0066
XUBE2A_01rs5910616
 GG32431.002563281.11 (0.64–1.92)
 AG or AA291.0080856.35 (1.00–40.40)
Pinteraction0.034
  • aAdjusted for age (continuous), gender, race, and BMI.