Table 3.

Relationship between family history and risk of second breast cancer stratified by menopausal status among women with carcinoma in situ of the breast

Pre-/PerimenopausalPostmenopausal
ControlsAll casesControlsAll cases
n (%)n (%)OR (95% CI)an (%)n (%)OR (95% CI)a
First-degree family history of breast cancer
 No270 (70.5)147 (67.7)1 [Ref]438 (75.8)208 (68.0)1 [Ref]
 Yes113 (29.5)70 (32.3)1.15 (0.77–1.71)140 (24.2)98 (32.0)1.56 (1.13–2.16)
No. of first-degree relatives with breast cancer
 0270 (70.9)147 (67.7)1 [Ref]438 (76.0)208 (68.2)1 [Ref]
 199 (26.0)57 (26.3)1.02 (0.66–1.60)115 (20.0)80 (26.2)1.52 (1.07–2.17)
 2+12 (3.2)13 (6.0)2.30 (0.97–5.48)23 (4.0)17 (5.6)1.75 (0.88–3.49)
Age at diagnosis of first-degree family member
 No history270 (71.2)147 (67.7)1 [Ref]438 (77.3)208 (70.3)1 [Ref]
 ≥5076 (20.1)37 (17.1)0.82 (0.49–1.39)91 (16.1)57 (19.3)1.39 (0.93–2.06)
 <5033 (8.7)33 (15.2)2.02 (1.14–3.59)38 (6.7)31 (10.5)1.80 (1.03–3.13)
  • aModels were implicitly adjusted for matching factors, no further adjustment.