Table 2.

Performance of PRS based on pancreatic cancer susceptibility variants in the GWAS of breast cancer in the African diaspora

Percentile of PRSCases (n = 1,657)Controls (n = 2,029)ORa (95% CI)
<51652040.99 (0.76–1.27)
5–101682001.02 (0.79–1.32)
10–201552140.85 (0.66–1.10)
20–401582110.88 (0.68–1.13)
40–603364001.00 (ref)
60–801711991.00 (0.78–1.29)
80–901662010.98 (0.76–1.27)
90–951731971.01 (0.78–1.30)
>951652030.97 (0.75–1.25)
Continuous (per SD = 0.571)1.01 (0.95–1.08)
  • aORs are for different percentiles of the polygenic PRS relative to the middle quintile (40%–60%) and were adjusted for age, study site, and the first four eigenvectors from principal components analysis.