Table 2.

Separate and mutually adjusted associations of BMI and presence of the MetS with breast cancer, Women's Health Initiative CVD Biomarkers Sub-Cohort

A. Separate
BMI (kg/m2)Cases (n = 1,176)Noncases (n = 19,768)HRa (95% CI)
18.5–<25.02404,8901.00 (Ref.)
25.0–<30.03897,1981.12 (0.95–1.33)
≥30.05477,6801.51 (1.28–1.78)
Ptrend<0.0001
MetS
 No68212,3791.00 (Ref.)
 Yes4947,3891.28 (1.13–1.44)
B. Mutually adjusted
BMI (kg/m2)Cases (n)Noncases (n)HRa (95% CI)
18.5–<25.02404,8901.00 (Ref.)
25.0–<30.03897,19811.09 (0.92–1.30)
≥30.05477,6801.42 (1.18–1.70)
Ptrend<0.0001
MetS
 No68212,3791.00 (Ref.)
 Yes4947,3891.18 (1.04–1.34)
  • aAdjusted for age (continuous), smoking status (never, former, current), pack-years of smoking (continuous), alcohol intake (drinks/week – continuous), physical activity (MET-h/wk), age at first birth (<20, 20–29, ≥30, missing), age at menarche (<12, 12, 13, ≥14), age at menopause (<45, 45–54, ≥55, missing), oral contraceptives (never, ever), hormone therapy (never, ever), parous/nulliparous, family history of breast cancer in first-degree relative (no, yes), history of breast biopsy (no, yes), breastfed for more than 6 months (no, yes), education (less than high school grad, high school grad/some college, college grad, post-college), ethnicity (white, black, other), allocation to the OS or specific arm of clinical trials.