Table 2.

Multivariable predictors of genetic testing uptake

(N = 781a)
Primary variables of interestMean (SD)/N (%)OR (95% CI)bOR0.5 SDc (95% CI0.5 SD)P
Precounseling cancer distress15.18 (14.24)1.01 (1.002–1.03)1.11 (1.01–1.21)0.026
Precounseling perceived comparative risk2.99 (1.10)1.32 (1.11–1.57)1.16 (1.06–1.28)0.002
Perceptions of patient-centeredness4.25 (0.48)0.45 (0.30–0.68)0.83 (0.75–0.91)0.0001
Covariates
Residence
 Urban (ref.)658 (84.25)0.057
 Rural123 (15.75)1.57 (0.99–2.49)
Relatives with breast or ovarian cancer
 0 FDR/SDR (ref.)411 (52.62)0.010
 1 FDR/SDR216 (27.66)1.45 (0.96–2.21)
 ≥2 FDR/SDR154 (19.72)2.09 (1.29–3.40)
Intervention
 In-person (ref.)379 (48.53)
 Telephone402 (51.47)0.53 (0.37–0.76)0.0005
Short-term cost concerns
 Yes (ref.)138 (17.67)
 No643 (82.33)18.73 (7.09–49.46)<0.0001
Long-term cost concerns
 Yes (ref.)27 (3.46)
 No754 (96.54)6.64 (1.15–38.41)0.034
Social support8.53 (1.91)0.90 (0.82–0.99)0.91 (0.83–0.99)0.035
Decisional conflict27.9 (13.39)0.95 (0.94–0.97)0.72 (0.65–0.80)<0.0001
  • Abbreviations: FDR, first-degree relative; ref., reference group; SDR, second-degree relative.

  • aModel shows estimates after adjustment for other variables.

  • bORs per one-point increase on the scale for continuous variables.

  • cEquivalent ORs and 95% CI per 0.50 SD increase in continuous variables; provided to aid clinical interpretation. Categorical ORs and 95% CI estimates remain the same as footnote “b”.

  • The goodness of fit of this model indicated adequate model fit (P = 0.43).