Table 1.

Adjusted ORs and 95% CI for alcohol, smoking, physical activity, height, and BMI associated with breast cancer overall

Breast cancer overall
	Cases	Controls	OR^a (95% CI)
Alcohol intake per week, current^a
Never drinkers	725	4,581	1 (Ref)
1 glass	935	5,399	1.07 (0.96–1.19)
2 glasses	850	4,853	1.07 (0.96–1.20)
3–4 glasses	1,073	5,887	1.11 (1.00–1.24)
5–6 glasses	448	2,305	1.16 (1.02–1.33)
6+ glasses	371	1,735	1.26 (1.09–1.45)
P_trend^b			0.001
Beer intake per week^c
Never drinkers	725	4,581	1 (Ref)
1 glass	921	5,123	1.11 (0.84–1.47)
2 glasses	387	2,168	1.08 (0.78–1.50)
3–4 glasses	178	833	1.09 (0.77–1.53)
5+ glasses	47	230	1.17 (0.80–1.73)
P_trend			0.14
Liquor intake per week^c
Never drinkers	725	4,581	1 (Ref)
1 glass	934	5,278	1.15 (0.87–1.51)
2 glasses	234	1,447	1.33 (0.95–1.87)
3–4 glasses	96	505	1.48 (0.95–2.29)
5+ glasses	34	126	0.84 (0.38–1.86)
P_trend			0.41
Wine intake per week^c
Never drinkers	725	4,581	1 (Ref)
1 glass	1,342	7,581	1.00 (0.76–1.32)
2 glasses	794	4,519	0.97 (0.66–1.44)
3–4 glasses	820	4,483	0.76 (0.44–1.30)
5+ glasses	480	2,351	0.95 (0.39–2.35)
P_trend			0.63
Smoking^d
Never	1,748	10,000	1 (Ref)
Past	1,579	8,572	1.06 (0.98–1.15)
Current	1,075	5,726	1.13 (1.03–1.23)
P_trend			0.006
Number of cigarettes per day, current^d
Never smokers	1,748	10,000	1 (Ref)
1–4	262	1,407	1.11 (0.95–1.29)
5–9	373	2,200	1.09 (0.95–1.24)
10–19	390	1,934	1.22 (1.06–1.39)
20+	73	285	1.41 (1.06–1.89)
P_trend			0.001
Pack-years of smoking^d
<2.5	1,461	9,061	1 (Ref)
2.5–4.9	151	757	1.24 (1.01–1.52)
5.0–9.9	252	1,359	1.14 (0.97–1.35)
10.0–14.9	258	1,294	1.23 (1.04–1.44)
15–19.9	162	943	0.99 (0.82–1.21)
≥20	325	1,540	1.26 (1.08–1.46)
P_trend			0.004
Low- and high-intensity physical activity per week, current^e
Never	166	817	1 (Ref)
1 hour	540	2,896	0.91 (0.75–1.10)
2–3 hours	2,055	11,000	0.90 (0.75–1.07)
4–5 hours	974	5,896	0.81 (0.67–0.97)
6+ hours	661	3,862	0.84 (0.70–1.02)
P_trend			0.01
Height/cm^f
<159 cm	393	2,677	1 (Ref)
160–164 cm	1,166	6,969	1.11 (0.98–1.25)
165–169 cm	1,412	8,139	1.13 (1.00–1.28)
170–174 cm	1,025	5,238	1.23 (1.08–1.41)
175–179	340	1,480	1.40 (1.19–1.66)
>180 cm	66	257	1.55 (1.15–2.09)
P_trend			<0.0001
BMI (kg/m²)
<20	164	1,100	1 (Ref)
20–21	199	1,237	1.06 (0.85–1.33)
22–23	692	4,174	1.10 (0.92–1.32)
24–25	935	5,530	1.13 (0.95–1.35)
26–27	837	4,527	1.24 (1.03–1.48)
28–29	591	3,197	1.22 (1.01–1.48)
>29	984	4,995	1.32 (1.10–1.58)
P_trend			<0.0001

↵^aAlcohol additionally adjusted for physical activity (never, 1 hour, 2–3 hours, 4–5 hours, 6+ hours) and smoking (never, past, and current).
↵^bP_trend and OR mutual adjusted BMI (≤22, 23–25, 26–28, >28 at screening), education (no education/primary school, high school, bachelor, and master), age at menarche (9–12, 13, 14, 15–18), number of pregnancies (never, 1, 2, 3, ≥4), and menopausal status (pre-, peri-, postmenopausal).
↵^cType of alcohol mutual adjusted for each other.
↵^dSmoking additionally adjusted for alcohol (never drinkers, 1 glass, 2 glasses, 3–4 glasses, 5+ glasses) and physical activity (never, 1 hour, 2–3 hours, 4–5 hours, 6+ hours).
↵^ePhysical activity additionally adjusted for alcohol (never drinkers, 1 glass, 2 glasses, 3–4 glasses, 5+ glasses) and smoking (never, past and current).
↵^fHeight additionally adjusted for weight.