Table 3.

Change from baseline to 30 months in the log-transformed (normalized) biomarkers by category of weight loss (all participants combined)

Baseline30 Months
Weight change Baseline to 30 monthsNGM (95% CI)9NGM (95% CI)Absolute change (%)Pa
VEGF
 Lost ≤0%33286.7 (233.1–352.7)30257.4 (202.2–327.7)−29.3 (−10.2).
 Lost 0–5%53312.0 (266.6–365.1)51279.1 (233.0–334.3)−32.9 (−10.5)0.84
 Lost 5–10%37302.1 (239.4–381.2)31266.3 (201.5–351.9)−35.8 (−11.9)0.13
 Lost ≥10%32291.1 (219.6–385.9)32226.1 (169.5–301.6)−65.0 (−22.3)0.002
PEDF
 Lost ≤0%3310.32 (9.59–11.11)3011.95 (11.04–12.94)1.63 (15.76).
 Lost 0–5%5310.93 (10.37–11.51)5111.33 (10.79–11.89)0.40 (3.67)0.02
 Lost 5–10%3710.30 (9.73–10.91)3110.64 (10.02–11.29)0.34 (3.26)0.01
 Lost ≥10%3210.34 (9.68–11.05)329.54 (8.94–10.19)−0.80 (−7.73)<0.001
  • aA P value obtained from a GEE model comparing the change from baseline to 30 months in the (log-transformed) biomarkers between higher levels of weight loss percentage to lowest level (Loss ≤ 0%).