Table 3.

SNP–breast cancer associations for SNPs in selected candidate genes [N = 3,334; 1,810 in subcohort (66 cases) and 1,524 additional cases]

SNP–Breast cancer association rankOverall rank for GxESNPLocationGeneHR (95% CI)P
143rs223813512: 48278190VDR1.17 (1.04–1.30)0.007
22rs1116828712: 48285414VDR1.13 (1.03–1.25)0.01
311rs198996912: 48278010VDR0.89 (0.81–0.98)0.02
434rs223813612: 48277713VDR1.14 (1.02–1.28)0.02
54rs423785512: 48287203VDR1.11 (1.01–1.23)0.03
66rs451603512: 48299826VDR0.90 (0.82–1.00)0.05
717rs285356412: 48278487VDR0.91 (0.83–1.01)0.06
869rs713653412: 48294626VDR0.91 (0.81–1.01)0.09
91rs432826212: 48285648VDR1.09 (0.98–1.20)0.10
1064rs224846120: 52792202CYP24A11.07 (0.97–1.17)0.18
1148rs225421012: 48273714VDR0.93 (0.85–1.03)0.18
1259rs224835920: 52791518CYP24A11.06 (0.97–1.17)0.20
1349rs13528444: 72647749GC1.09 (0.95–1.25)0.22
1447rs10455709: 137332311RXRA1.08 (0.95–1.23)0.26
1526rs1157414312: 48234917VDR0.91 (0.78–1.07)0.26
1681rs780777369: 137257165RXRA1.13 (0.91–1.40)0.27
175rs1788398412: 48293716VDR0.94 (0.85–1.05)0.28
1825rs218187420: 52784478CYP24A11.06 (0.95–1.18)0.29
1929rs229624120: 52786219CYP24A10.95 (0.86–1.05)0.29
2062rs223918012: 48256046VDR0.92 (0.79–1.08)0.31
2161rs37333594: 72649774GC0.92 (0.78–1.10)0.37
2274rs96159: 137331525RXRA0.90 (0.70–1.15)0.39
2332rs75734312: 48239675VDR0.94 (0.81–1.09)0.42
2428rs224809812: 48253356VDR1.04 (0.94–1.14)0.44
2546rs1116827512: 48272275VDR1.04 (0.93–1.17)0.45
2630rs276293420: 52771261CYP24A11.04 (0.92–1.18)0.50
2767rs1087701212: 58162085CYP27B11.04 (0.93–1.15)0.51
2819rs796715212: 48244184VDR1.03 (0.94–1.13)0.53
2918rs222857212: 48272840VDR0.91 (0.67–1.24)0.55
3076rs1116826712: 48251542VDR0.95 (0.80–1.13)0.56
3121rs49173549: 137237661RXRA0.97 (0.88–1.08)0.58
3237rs1089819311: 71197083NADSYN10.97 (0.85–1.09)0.59
3340rs356036359: 137323202RXRA0.93 (0.71–1.21)0.59
3444rs6174968920: 52790005CYP24A10.92 (0.66–1.26)0.60
3565rs2220094: 72631735GC1.11 (0.76–1.62)0.60
3671rs1157402612: 48288246VDR0.96 (0.82–1.12)0.61
377rs223918212: 48255411VDR0.98 (0.89–1.07)0.61
383rs11791312411: 14900931CYP2R10.92 (0.67–1.27)0.62
3966rs43642284: 72623347GC1.04 (0.89–1.22)0.63
4010rs31185369: 137308462RXRA1.03 (0.91–1.17)0.64
4150rs1271799112: 48259126VDR0.98 (0.89–1.08)0.66
4231rs972912: 48236623VDR1.02 (0.93–1.12)0.68
4357rs154033912: 48257326VDR0.98 (0.89–1.09)0.72
4460rs70380189: 137309959RXRA0.98 (0.85–1.12)0.72
458rs31323019: 137294030RXRA0.98 (0.87–1.11)0.74
469rs31322969: 137302631RXRA0.98 (0.89–1.09)0.74
4745rs157066920: 52774427CYP24A10.98 (0.89–1.09)0.75
4878rs602298720: 52770596CYP24A11.02 (0.92–1.12)0.75
4977rs378290512: 48266167VDR1.02 (0.92–1.13)0.76
5020rs223917912: 48257766VDR1.01 (0.92–1.12)0.77
5113rs111029869: 137285503RXRA0.98 (0.87–1.11)0.78
5214rs712978111: 14912417CYP2R11.02 (0.86–1.21)0.80
5380rs92765020: 52772741CYP24A10.99 (0.90–1.08)0.80
5453rs7051204: 72614140GC1.01 (0.92–1.11)0.80
5522rs11555634: 72643488GC0.99 (0.89–1.10)0.80
5668rs228334212: 48255859VDR0.98 (0.86–1.13)0.81
5727rs223918612: 48269410VDR1.02 (0.90–1.15)0.81
5816rs88644112: 48262964VDR1.01 (0.90–1.14)0.83
5938rs104453511: 71145778DHCR70.98 (0.83–1.17)0.84
6033rs222857012: 48272895VDR0.99 (0.90–1.09)0.85
6135rs1699911620: 52777467CYP24A10.99 (0.86–1.13)0.87
6263rs14330442011: 71144815DHCR70.98 (0.74–1.29)0.87
6372rs343121369: 137269456RXRA1.01 (0.91–1.11)0.87
6473rs1074165711: 14914878CYP2R10.99 (0.90–1.09)0.88
6536rs3587357920: 52788190CYP24A10.98 (0.72–1.32)0.88
6654rs1278587811: 71167449NADSYN11.01 (0.91–1.12)0.89
6770rs1190735020: 52770439CYP24A10.98 (0.77–1.26)0.89
6879rs1087569312: 48269650VDR1.01 (0.91–1.12)0.89
6942rs381954512: 48265006VDR0.99 (0.90–1.10)0.90
7058rs678162429: 137268441RXRA1.01 (0.90–1.13)0.90
7155rs65379989: 137292505RXRA1.02 (0.74–1.40)0.90
7241rs797512812: 48245828VDR0.99 (0.90–1.10)0.90
7356rs2220204: 72636272GC0.99 (0.88–1.12)0.91
7415rs1279471411: 14913575CYP2R10.99 (0.90–1.09)0.91
7575rs229623920: 52775528CYP24A11.01 (0.90–1.12)0.92
7623rs18053439: 137328286RXRA1.00 (0.90–1.10)0.94
7712rs350791689: 137280939RXRA1.00 (0.91–1.11)0.94
7852rs111856609: 137259992RXRA1.00 (0.90–1.12)0.95
7924rs45884: 72618323GC1.00 (0.90–1.11)0.97
8039rs480995820: 52782438CYP24A11.00 (0.88–1.14)0.97
8151rs73123612: 48238757VDR1.00 (0.91–1.10)0.97
8282rs210730112: 48255570VDR1.00 (0.90–1.11)0.99