Table 3.

Relative risks of breast cancer associated with a family history of breast cancer by age and year of diagnosis, BCSC 1996–2012 and CBCS 1987–2007

BCSCCBCS
Total at entry (N = 1,170,900)Cases (N = 22,795)HR (95% CI)aControls (N = 26,460)Cases (N = 23,400)OR (95% CI)a
Age at breast cancer diagnosis (years)
 40–49471,3066,6261.81 (1.70–1.92)5,3814,7901.88 (1.67–2.11)
 50–59363,2377,4541.60 (1.51–1.69)8,6637,5611.56 (1.43–1.69)
 60–74336,3578,7151.50 (1.42–1.58)12,41611,0491.63 (1.52–1.74)
Age and year of diagnosis
 Age 40–49 years
  1987–1993NANANA1,8561,1801.82 (1.46–2.27)
  1994–199955,6061,5171.75 (1.54–2.00)1,9872,0572.07 (1.72–2.48)
  2000–2004158,3842,8251.86 (1.69–2.05)1,1561,1391.73 (1.37–2.18)
  2005–2009180,8502,1321.79 (1.61–2.00)3824141.43 (0.96–2.15)
  2010–201376,4661522.36 (1.64–3.40)NANANA
TrendP = 0.28P = 0.23
 Age 50–59 years
  1987–1993NANANA3,7382,6211.54 (1.34–1.77)
  1994–199945,3631,9011.55 (1.38–1.74)2,5532,7031.60 (1.38–1.85)
  2000–2004129,1013,2701.63 (1.49–1.79)1,7911,6441.38 (1.15–1.64)
  2005–2009137,3252,1571.77 (1.60–1.96)5815931.80 (1.33–2.44)
  2010–201351,4481261.48 (0.97–2.25)NANANA
TrendP = 0.24P = 0.88
 Age 60–74 years
  1987–1993NANANA7,4416,3271.68 (1.54–1.84)
  1994–199959,9032,2821.61 (1.45–1.77)2,9652,7891.69 (1.48–1.94)
  2000–2004119,0413,6491.52 (1.40–1.65)1,5041,4561.50 (1.26–1.80)
  2005–2009114,1462,5941.47 (1.34–1.62)5064771.29 (0.94–1.76)
  2010–201343,2671901.34 (0.95–1.87)NANANA
TrendP = 0.08P = 0.08
  • Abbreviation: NA, not available.

  • aModels adjusted for single year of age, race/ethnicity, and history of benign breast biopsy and registry/state of residence. Reference category for all models defined as women reporting no family history of breast cancer (BCSC, n = 1,025,508; CBCS controls n = 22,875, cases n = 18,479).