Table 2.

Twelve- and 30-month changes in BMI and in angiogenesis biomarkers by randomization arm

Time pointP
Baseline12 Months30 Months
Randomization armNGM (95% CI)NGM (95% CI)NGM (95% CI)0–12 Months change (%)0–30 Months change (%)P12unadjP12adjP30unadjP30adj
BMI
 Control2530.42 (28.99–31.93)2530.61 (29.03–32.28)2429.55 (27.77–31.43)0.19 (0.62)−0.88 (−2.88)....
 Diet4529.88 (28.85–30.94)4526.30 (25.14–27.51)4527.89 (26.69–29.15)−3.58 (−12.0)−1.98 (−6.64)<0.001<0.0010.050.05
 Exercise4428.87 (27.95–29.83)4428.32 (27.35–29.32)4428.27 (27.24–29.33)−0.56 (−1.93)−0.61 (−2.11)0.020.020.470.45
 Diet+Ex4230.46 (29.28–31.69)4226.28 (25.13–27.47)4228.05 (26.86–29.29)−4.19 (−13.7)−2.41 (−7.92)<0.001<0.0010.0050.005
VEGF
 Control25304.4 (236.7–391.4)25318.0 (243.2–415.9)23290.6 (221.1–381.8)13.63 (4.48)−13.8 (−4.54)....
 Diet45321.3 (268.6–384.3)45289.1 (241.4–346.3)43276.1 (224.0–340.2)−32.1 (−10.0)−45.2 (−14.1)<0.001<0.0010.020.02
 Exercise44269.4 (218.5–332.2)44267.1 (215.3–331.4)39216.5 (171.3–273.5)−2.29 (−0.85)−52.9 (−19.7)0.130.1260.0020.003
 Diet+Ex42312.2 (252.1–386.6)42284.2 (230.2–350.8)39267.0 (210.5–338.7)−28.0 (−8.97)−45.2 (−14.5)<0.001<0.0010.0020.002
PEDF
 Control2511.37 (10.60–12.202511.24 (10.50–12.042311.79 (10.75–12.93−0.13 (-1.16)0.42 (3.68)....
 Diet4510.68 (10.06–11.34459.19 (8.66–9.774310.59 (9.92–11.32−1.49 (−13.9)−0.09 (−0.84)<0.001<0.0010.410.42
 Exercise449.95 (9.46–10.46449.94 (9.46–10.45)3910.98 (10.32–11.68)−0.01 (−0.08)1.03 (10.35)0.720.720.210.19
 Diet+Ex4210.50 (9.88–11.16)429.25 (8.77–9.75)3910.53 (10.02–11.07)−1.25 (−11.9)0.03 (0.29)<0.001<0.0010.460.48
  • NOTE: P12unadj was obtained from a GEE model comparing changes in the biomarkers from baseline with 12 months between intervention versus control arm, unadjusted. P12adj was obtained from a GEE model comparing changes in the biomarkers from baseline with 12 months between intervention versus control arm, adjusted for baseline age, baseline BMI (<30 kg/m2, ≥30 kg/m2), and race/ethnicity. P30unadj was obtained from a GEE model comparing changes in the biomarkers from baseline with 30 months between intervention versus control arm, unadjusted. P30adj was obtained from a GEE model comparing changes in the biomarkers from baseline with 30 months between intervention vs control arm, adjusted for baseline age, baseline BMI (<30 kg/m2, ≥30 kg/m2), and race/ethnicity.