Table 2.

Relative risks of breast cancer associated with a first-degree family history of breast cancer by year and stage of disease at diagnosis, BCSC 1996–2012 and CBCS 1987–2007

VariableBCSCCBCS
Total at entry (N = 1,170,900)N, Cases (N = 22,795)HR (95% CI)aControls (N = 26,460)Cases (N = 23,400)OR (95% CI)a
Any first-degree family history145,3924,4221.61 (1.55–1.66)3,5854,9211.64 (1.57–1.72)
 1101,9112,9531.58 (1.52–1.64)3,2844,2831.57 (1.49–1.65)
 >110,5364071.88 (1.70–2.07)3016382.47 (2.15–2.84)
 Unspecifiedb32,9451,0621.60 (1.50–1.70)00
Year of diagnosis
 1987–1993NANANA13,03510,1281.65 (1.54–1.78)
 1994–1999160,8725,7001.60 (1.49–1.70)7,5057,5491.74 (1.59–1.90)
 2000–2004406,5269,7441.64 (1.56–1.73)4,4514,2391.50 (1.34–1.67)
 2005–2009432,3216,8831.67 (1.57–1.77)1,4691,4841.51 (1.24–1.82)
 2010–2013171,1814681.68 (1.35–2.07)NANANA
TrendP = 0.40P = 0.06
Stage of disease at diagnosis
 DCIS1,170,9004,9791.63 (1.51–1.75)10,9662,3281.78 (1.59–1.99)
 Localized1,170,90011,4541.68 (1.61–1.76)26,46012,7671.69 (1.60–1.79)
 Regional/distant1,170,9005,1231.58 (1.47–1.70)26,4606,1981.46 (1.36–1.57)
Stage and year of diagnosis
 DCIS
  1987–1993NANANANANANA
  1994–1999160,8721,2071.77 (1.54–2.04)7,1051,3371.90 (1.64–2.19)
  2000–2004406,5262,0471.54 (1.37–1.73)2,3928321.59 (1.31–1.94)
  2005–2009432,3211,6121.63 (1.44–1.84)1,4691591.71 (1.15–2.54)
  2010–2013171,1811131.59 (1.02–2.49)NANANA
TrendP = 0.26P = 0.27
 Localized
  1987–1993NANANA13,0355,5871.73 (1.59–1.88)
  1994–1999160,8722,8061.54 (1.40–1.69)7,5054,1661.78 (1.61–1.96)
  2000–2004406,5264,9431.73 (1.61–1.86)4,4512,2351.56 (1.37–1.77)
  2005–2009432,3213,4781.73 (1.59–1.87)1,4697791.44 (1.15–1.81)
  2010–2013171,1812271.82 (1.35–2.45)NANANA
TrendP = 0.04P = 0.03
 Regional/distant
  1987–1993NANANA13,0353,0721.53 (1.37–1.70)
  1994–1999160,8721,2021.61 (1.40–1.86)7,5051,6731.52 (1.32–1.75)
  2000–2004406,5262,3141.56 (1.39–1.74)4,4511,0461.28 (1.07–1.53)
  2005–2009432,3211,5001.58 (1.39–1.79)1,4694071.42 (1.06–1.88)
  2010–2013171,1811071.66 (1.06–2.60)NANANA
TrendP = 0.76P = 0.12
  • Abbreviation: NA, not available.

  • aModels adjusted for single year of age, race/ethnicity, history of benign breast biopsy, and registry/state of residence. Reference category for all models defined as women reporting no family history of breast cancer (BCSC, n = 1,025,508; CBCS controls n = 22,875, cases n = 18,479).

  • bUnknown number of affected family members (1 or more).