Table 3.

Risk of indicated outcomes by vasectomy status and trial arm

Control armScreening arm
No vasectomyVasectomyNo vasectomyVasectomy
HRHR (95% CI)PHRHR (95% CI)P
Gleason 8–10
 Age adjusted1.00.93 (0.76–1.14)0.491.01.05 (0.85–1.30)0.64
  (n)387/26,049123/9,924333/27,093117/10,021
  Time at risk, y268,492104,935278,234105,386
 Adjusteda1.01.06 (0.84–1.33)0.611.01.09 (0.86–1.38)0.46
  (n)299/21,278105/8.337286/22,458100/8,491
  Time at risk, y219,47688,086230,96289,209
Gleason 7
 Age adjusted1.01.01 (0.89–1.15)0.851.01.01 (0.89–1.14)0.91
  (n)933/26,049358/9,924996/27,093360/10,021
  Time at risk, y268,492104,935278,234105,386
 Adjusteda1.01.07 (0.94–1.23)0.291.01.06 (0.93–1.21)0.42
  (n)785/21,278315/8,337831/22,458314/8,491
  Time at risk, y219,47688,086230,96289,209
Gleason 2–6
 Age adjusted1.01.12 (1.01–1.23)0.03b1.00.99 (0.90–1.08)0.83
  (n)1,434/26,049588/9,9241,823/27,093647/10,021
  Time at risk, y268,492104,935278,234104,935
 Adjusteda1.01.15 (1.03 -1.27)0.01b1.01.01 (0.91–1.11)0.91
  (n)1,200/21,278517/8,3371,532/22,458564/8,491
  Time at risk, y219,47688,086230,96289,209
Advanced prostate cancer
 Age adjusted1.00.98 (0.79–1.21)0.841.01.10 (0.91–1.34)0.32
  n329/26,075121/9,933367/27,140146/10,032
  Time at risk, y268,637104,981278,41210,542
 Adjustedb1.01.00 (0.79–1.26)0.9931.01.15 (0.93–1.42)0.19
  (n)272/21,300101/8,343312/22,500128/8,501
  Time at risk, y219,60488,112231,13289,243
Lethal prostate cancer
 Age adjusted1.01.18 (0.80–1.73)0.411.00.73 (0.47–1.12)0.14
  (n)103/26,07536/9,933116/27,14026/10,032
  Time at risk, y268,637104,981278,41210,542
 Adjustedb1.01.18 (0.76–1.83)0.461.00.76 (0.47–1.22)0.26
  (n)85/21,30028/8,34398/22,50022/8,501
  Time at risk, y219,60488,112231,13289,243
  • NOTE: (n) Denotes number of subjects with prostate cancer in each category over total number in that category.

  • aAdjusted for age, BMI, smoking (pack years), family history of prostate cancer (no, or yes + maybe), black race, Hispanic identification, aspirin use, diabetes, hypertension, reported history of PSA testing in previous 3 years (none, once, and more than once), and digital rectal exam in the past three years (none, once, and more than once).

  • bP < 0.05 for comparison between vasectomy and no vasectomy within each study arm.