Table 2.

HRs for the effect of Indigenous American ancestry on primary and secondary outcomes

Breast cancer recurrenceBreast cancer–specific mortalityAll-cause mortalityDisease-free survival
Crude HR (95% CI)Adjusted HRa (95% CI)Crude HR (95% CI)Adjusted HRa (95% CI)Crude HR (95% CI)Adjusted HRa (95% CI)Crude HR (95% CI)Adjusted HRa (95% CI)
Indigenous American ancestryb1.00 (0.86–1.16)0.98 (0.84–1.15)0.95 (0.77–1.17)0.97 (0.78–1.19)0.93 (0.80–1.08)0.98 (0.83–1.14)0.96 (0.85–1.08)0.98 (0.87–1.10)
Age at diagnosis0.99 (0.96–1.00)1.00 (0.98–1.03)1.02 (1.00–1.04)1.01 (1.00–1.03)
AJCC Stage
 Stage I–IIrefrefrefref
 Stage III–IV4.01 (2.3–7.1)7.35 (3.60–15.0)4.61 (2.65–8.03)3.65 (2.31–5.76)
Hormonal therapy
 Norefrefrefref
 Yes0.56 (0.32–0.97)0.49 (0.24–1.00)0.39 (0.23–0.66)0.57 (0.37–0.88)
  • aAdjusted for age at diagnosis (years), AJCC stage, and hormonal therapy.

  • bPer 10% increase in ancestry.