Table 3.

Nominally significant genetic correlations between cancers and noncancer traits

CancerNoncancer traitrgSEPEpidemiologic observationsReference
Breast cancerUlcerative colitis0.2430.080.002+55
Breast cancerSchizophrenia0.1420.0490.004+56
Breast cancerHeight0.1430.0550.01+57
Breast cancerTriglycerides−0.130.0610.03358
Breast cancerBMI−0.1120.0530.035− (premenopausal)35
+ (postmenopausal)
Colorectal cancerBMI0.1570.0466.22E−04+35
Colorectal cancerTriglycerides0.1260.0580.029+59
Colorectal cancerSchizophrenia−0.0910.0460.048No association56
Lung cancerEver/never smoked0.4120.0841.03E−06+60
Lung cancerHDL−0.1510.0630.01759
Lung cancerBMI0.1160.0540.032− (smokers)35
No association (nonsmokers)
Ovarian cancerType-2 diabetes0.4690.1910.014+61
Ovarian cancerUlcerative colitis0.2910.1370.034No association55
Pancreatic cancerHDL−0.4050.1670.015UnknownN/A
Pancreatic cancerBMI0.2430.1170.038+35
Prostate cancerBMI−0.0830.040.03935
  • NOTE: For each cancer-trait genetic correlation observed, current evidence from observational studies and corresponding reference are also listed. P values are not corrected for multiple testing.