Table 4.

Functional predictions (PolyPhen-2, SIFT) for protein-coding variants with a P value <1.0 × 10−4 from the common variant analysis among African Americans with incident NSCLC participating in the SCCS (N = 275)

SNPGeneaAmino acid changePolyPhen-2 predictionSIFT Prediction
rs1133358SUN5E > DBenignDeleterious
rs8176785NELL1R > QBenignTolerated
rs7626962SCN5AS > YBenignDeleterious
rs35761244CCDC130C > SBenignTolerated
rs1639122CHD4E > DBenignTolerated