Table 3.

Multivariable Cox proportional hazards results for African Americans with incident NSCLC and common variants assayed by the Illumina HumanExome BeadChip v1.1

SCCS (N = 275)KCI/WSU (N = 312)UCSF (N = 284)
SNPChrbp PositionaGenebHR (95% CI)PHR (95% CI)PHR (95% CI)P
rs113335820q11.2131590686SUN50.61 (0.49–0.76)8.12 × 10−61.01 (0.82–1.24)0.941.08 (0.87–1.35)0.49
rs817678511p15.120805286NELL11.65 (1.32–2.07)1.20 × 10−50.98 (0.79–1.21)0.821.11 (0.87–1.42)0.39
rs76269623p22.238620907SCN5A1.95 (1.44–2.64)1.44 × 10−51.05 (0.75–1.46)0.780.80 (0.53–1.22)0.30
rs6052036p21.3331847012SLC44A4 || EHMT20.46 (0.33–0.66)1.63 × 10−51.13 (0.82–1.57)0.430.55 (0.38–0.79)0.001
rs35761244c19p13.213873698CCDC1301.66 (1.32–2.09)1.68 × 10−50.98 (0.70–1.36)0.900.94 (0.68–1.32)0.73
rs6959964c7q11.2268905738|| AUTS21.56 (1.27–1.91)2.21 × 10−50.84 (0.67–1.04)0.100.88 (0.71–1.10)0.27
rs163912212p13.316711147CHD41.80 (1.36–2.38)3.38 × 10−50.93 (0.74–1.19)0.581.05 (0.78–1.40)0.76
rs713880312q13.1250247468BCDIN3D || FAIM21.70 (1.32–2.18)3.78 × 10−50.96 (0.74–1.24)0.740.90 (0.69–1.19)0.48
rs20726336p21.3331919578CFB0.66 (0.54–0.81)4.07 × 10−51.00 (0.81–1.23)0.980.91 (0.73–1.13)0.40
rs15052292p1277589901LRRTM40.67 (0.56–0.82)5.44 × 10−50.96 (0.78–1.19)0.721.04 (0.84–1.30)0.72
rs750221617q1236612948ARHGAP230.67 (0.55–0.81)5.78 × 10−50.85 (0.69–1.04))0.111.10 (0.89–1.36)0.40
rs5371606p21.3331916400CFB0.61 (0.48–0.78)7.44 × 10−50.98 (0.74–1.29)0.870.81 (0.61–1.06)0.13
rs7302017c12q14.163004583MIRLET7I || PPM1H1.53 (1.24–1.89)9.28 × 10−51.29 (1.01–1.63)0.040.87 (0.67–1.13)0.30
  • NOTE: Models are adjusted for age, sex, treatment, stage, and percent African ancestry. Results are shown for associations with a p value < 1.0 × 10−4.

  • adbSNP build 137/GRCH37.p5.

  • bFor variants outside of gene boundaries, || denotes the location of the variant relative to the closest gene(s).

  • cImputed in KCI/WSU and USCF populations. Imputation score = 0.90 for rs35761244, =0.98 for rs6959964, and =0.99 for rs7302017.