Table 5.

Associations between positivity for HPV species by genus and cytologic abnormalitiesa in the Ludwig-McGill Cohort Study (n = 503)

≥ASC-US (n = 32)≥LSIL (n = 16)
Unrestricted analysisbRestricted analysiscUnrestricted analysisbRestricted analysisc
GenusSpeciesnOR (95% CI)OR (95% CI)nOR (95% CI)OR (95% CI)
Alphadα-300.00 (0.00–4.19)0.00 (0.00–7.90)00.00 (0.00–9.12)0.00 (0.00–42.26)
α-523.42 (0.71–16.55)5.63 (1.12–28.35)13.18 (0.38–26.46)9.78 (1.00–95.51)
α-654.66 (1.61–13.51)7.04 (2.30–21.51)511.84 (3.72–37.67)27.15 (6.72–109.79)
α-710.86 (0.11–6.69)1.49 (0.19–11.95)00.00 (0.00–7.42)0.00 (0.00–34.83)
α-9138.52 (3.89–18.69)9.41 (4.15–21.35)1019.69 (6.79–57.12)25.72 (7.70–85.95)
α-1011.66 (0.20–13.49)2.81 (0.33–23.67)00.00 (0.00–14.62)0.00 (0.00–65.55)
Betaeβ-140.91 (0.31–2.68)0.93 (0.31–2.79)00.00 (0.00–1.64)0.00 (0.00–1.61)
β-261.34 (0.53–3.39)1.30 (0.51–3.30)20.81 (0.18–3.64)0.69 (0.15–3.10)
β-311.66 (0.20–13.49)1.66 (0.20–13.65)00.00 (0.00–14.62)0.00 (0.00–12.52)
  • aCytologic outcome defined at two cut-off points (ASC-US and LSIL). Two women had missing data on cytology.

  • bUnrestricted analysis compared women with a genus-specific species infection against a floating referent group of all women who did not have that particular species infection.

  • cRestricted analysis compared women with a genus-specific species infection against a fixed referent group of HPV-negative women (α referent group n=396, β negative group n=367).

  • dβ-HPV species: β-1 (HPVs 5, 8, 12, 14, 19, 21, 24, 36, 47, 105, 124); β-2 (HPVs 9, 15, 17, 22, 23, 38, 100, 107, 110, 111, 113, 120, 122, 151); β-3 (HPVs 49, 76).

  • eα-HPV species: α-3 (HPVs 61, 62, 72, 81, 83, 84, 89); α-5 (HPVs 26, 51, 69, 82); α-6 (HPVs 53, 56, 66); α-7 (HPVs 18, 39, 45, 59, 68, 70); α-9 (HPVs 16, 31, 33, 35, 52, 58, 67); α-10 (HPVs 6, 11, 44).