Table 2.

Multivariable Cox proportional hazards results for African Americans with incident NSCLC and the five SNPs previously associated with lung cancer survival in the NHGRI GWAS catalog assayed by the Illumina HumanExome BeadChip v1.1

SCCS (N = 275)KCI/WSU (N = 312)UCSF (N = 284)
SNPChr.bp PositionaGenebHR (95% CI)PHR (95% CI)PHR (95% CI)P
rs187802212q23.3108699032CMKLR10.70 (0.54–0.92)9.8 × 10−30.87 (0.66–1.14)0.300.94 (0.71–1.24)0.66
rs120995021q22.240173528|| ETS21.16 (0.90–1.50)0.240.93 (0.70–1.25)0.650.91 (0.68–1.22)0.53
rs998186121q22.241415044DSCAM1.08 (0.88–1.33)0.461.13 (0.91–1.39)0.271.15 (0.91–1.45)0.24
rs16564022q37.1233426526EIF4E20.93 (0.76–1.14)0.480.90 (0.72–1.11)0.301.11 (0.86–1.43)0.41
rs716274c11q22.3103418158DYNC2H1 ||1.02 (0.84–1.23)0.860.97 (0.80–1.17)0.721.21 (0.97–1.50)0.08
  • Models are adjusted for age, sex, treatment, stage, and percent African ancestry.

  • adbSNP build 137/GRCH37.p5.

  • bFor variants outside of gene boundaries, || denotes the location of the variant relative to the closest gene.

  • cImputed in KCI/WSU and USCF populations. Imputation score = 0.99.

  • HR = hazard ratio, CI = confidence interval.