Table 1.

Baseline demographics and physiologic characteristics in the WHI biospecimen cohort, stratified by CRP quartiles (n = 17,841)

CRP < 1.5 mg/L1.5 ≤ CRP < 2.39 mg/L2.39 ≤ CRP < 4.45 mg/L4.45 ≤ CRP ≤ 10 mg/L
Variablen = 4,433n = 4,470n = 4,470n = 4,468
Demographics%%%%
Age at screening (years)
 50 ≤ age < 602827.128.734.3
 60 ≤ age < 7042.844.345.646.8
 70 ≤ age < 8129.228.625.718.9
BMI group
 BMI < 2548.826.716.110.3
 25 ≤ BMI < 3035.842.139.730.3
 30 ≤ BMI <3511.622.228.433
 BMI ≥ 353.88.915.826.4
Some college education (0.8% missing)64.960.856.857.7
Ethnicity
 Black or African American30.53034.543
 Hispanic/Latino13.115.917.517.9
 White (not Hispanic)56.454.148.139.1
Randomized to one or more clinical trials79.379.67874.2
Use of menopausal HT (randomized or self-report)44.646.852.659.3
Randomized to menopausal HT
  Not randomized32.633.838.646.4
  Randomized to control32.833.430.425.9
  Estrogen only11.312.213.312.5
  Estrogen + Progesterone23.320.617.715.3
Diabetes/high blood sugar ever (19.3% missing)8.514.120.526.3
Hypertension (0.8% missing)30.536.242.248.7
Cardiovascular disease (5.6% missing)14.116.316.417.7
BC diagnosis5.46.45.97.2
Smoking (1.4% missing)
 Never54.254.152.650.7
 Past37.537.738.238.6
 Current8.48.29.210.7
Mean (SD)Mean (SD)Mean (SD)Mean (SD)
Age at screening (years)64.6 (7.47)64.7 (7.37)64.2 (7.37)62.9 (6.97)
BMI (kg/m2)25.9 (4.88)28.3 (5.13)30.0 (5.32)31.9 (5.90)
Weight (kg)67.5 (13.39)73.4 (14.26)77.7 (14.81)83.0 (16.54)
Physical activity (METs; 4.42% missing)13.5 (14.66)11.6 (13.61)10.0 (12.55)8.8 (11.84)
Pack-years (3.53% missing)7.9 (15.67)9.0 (17.98)8.9 (17.28)10.3 (19.02)
Alcohol consumption (servings/wk; 4.42% missing)2.2 (4.62)2.2 (5.78)1.6 (4.16)1.5 (4.45)
  • NOTE: P values for test of trend omitted from the table as all trends were statistically significant (P < 0.005) due to large sample size. Test of trend using simple linear regression with log(hsCRP).

  • Abbreviations: BC, breast cancer; METs, metabolic equivalents.