Table 3.

Performance of the gene signature within individual histopathologic subtypes

Signature classification
MalignantBenignIndeterminate
Melanoma subtype
 Nodular melanoma3810
 Nodular melanoma ex nevus100
 Superficial spreading melanoma2911
 Superficial spreading melanoma ex nevus410
 Acral melanoma600
 Acral lentiginous melanoma200
 Desmoplastic melanoma030
 Lentigo maligna melanoma200
 Nevoid melanoma700
 Spitzoid melanoma100
 Melanoma, NOS001
 Melanoma in situ100
Total9162
Nevi subtype
 Compound nevi0230
 Compound dysplastic nevi080
 Compound dysplastic nevi with severe atypia203
 Compound nevi with congenital and dysplastic features100
 Compound nevi with congenital features090
 Compound nevi with special site features001
 Intradermal nevi0210
 Intradermal nevi with congenital features030
 Intradermal nevi, mitotically active010
 Junctional nevi010
 Junctional dysplastic nevi011
 Pigmented spindle cell nevus020
 Spitz nevi010
 Spitz nevi with desmoplasia010
 Spitzoid dysplastic nevi010
 Combined nevi (blue and intradermal)010
 Combined nevi (desmoplastic and conventional features)010
 Acral nevi010
Total3755
  • Abbreviation: NOS, not otherwise specified.