Table 5.

ORs and HRs (95% CIs) for lung cancer and nut consumption in EAGLE and AARP, by histologic subtypes

Quintile of total nut consumption (frequency/d) in EAGLEQuintile of total nut consumption (frequency/d) in AARP
Nut consumptiona12345p-trend12345p-trend
Adenocarcinoma
 Cases/controls316/74860/12287/291129/397110/360760/49,0231,703/118,0801,823/142,9041,111/84,6311,022/84,503
 Crude1.001.160.710.770.720.0111.000.890.790.810.75<0.001
  (95% CI)(reference)(0.83–1.63)(0.54–0.93)(0.61–0.98)(0.56–0.93)reference(0.82–0.97)(0.72–0.85)(0.74–0.89)(0.68–0.82)
 Multivariableb1.000.890.710.870.790.1361.001.020.950.990.930.151
  (95% CI)(reference)(0.52–1.55)(0.51–1.00)(0.65–1.18)(0.58–1.08)reference(0.93–1.11)(0.87–1.04)(0.90–1.09)(0.85–1.03)
Squamous cell carcinoma
 Cases/Controls228/74811/12261/29183/39765/360462/49,023734/118,080927/142,904505/84,631497/84,503
 Crude1.000.300.690.690.590.0011.000.630.660.610.60<0.001
  (95% CI)(reference)(0.16–0.56)(0.50–0.94)(0.52–0.91)(0.44–0.80)(reference)(0.57–0.71)(0.59–0.73)(0.54–0.69)(0.53–0.68)
 Multivariableb1.001.080.810.960.740.1251.000.790.870.810.830.004
  (95% CI)(reference)(0.44–2.68)(0.54–1.20)(0.67–1.38)(0.50–1.09)(reference)(0.70–0.89)(0.78–0.98)(0.71–0.93)(0.72–0.94)
Small cell carcinoma
 Cases/Controls87/74812/12221/29131/39726/360310/49,023578/118,080625/142,904344/84,631284/84,503
 Crude1.000.850.620.670.620.0401.000.750.660.620.51<0.001
  (95% CI)(reference)(0.45–1.59)(0.38–1.02)(0.44–1.03)(0.39–0.98)(reference)(0.65–0.86)(0.58–0.76)(0.53–0.72)(0.44–0.60)
 Multivariableb1.001.410.910.890.960.8871.000.950.920.880.760.002
  (95% CI)(reference)(0.56–3.58)(0.52–1.59)(0.53–1.49)(0.56–1.65)(reference)(0.83–1.10)(0.80–1.06)(0.75–1.03)(0.65–0.90)
  • NOTE: Unless otherwise indicated, data are reported as OR (95% CI) for EAGLE and HR (95% CI) for AARP.

  • aNut consumption in sex-specific quintiles based on distribution of controls for each sex for EAGLE: quintile 1 (nonconsumers), quintile 2 (1–6 times/y), quintile 3 (7–11 times/y), quintile 4 (once a month up to 3 times a month), and quintile 5 (once a week up to 5 times a week, and once a day up to 2 or more times a day); nut consumption in sex-specific quintiles based on distribution of controls for AARP: quintile 1 (nonconsumers), quintile 2 (1–6 times/y), quintile 3 (7–11 times/y), quintile 4 (once a month up to 2–3 times a month), and quintile 5 (once a week up to 6 times a week, and once a day up to 2 or more times a day).

  • bAdjusted for age, sex, area of residence, education, BMI, cigarette smoking status, cumulative pack-years of cigarette smoking (continuous, 0 for never smokers), years since last cigarette smoked (continuous, 0 for never smokers), and intakes of red and processed meat, fruits, vegetables, and alcohol in EAGLE; adjusted for age, sex, education, BMI, energy intake, cigarette smoking status, cigarette smoking dose (categorical, 0 for never smokers), years since last cigarette smoked (categorical, 0 for never smokers), and intakes of red and processed meat, fruits, vegetables, and alcohol for AARP.