Table 3.

Associations between simple or detailed breast cancer family history and incident invasive breast cancer, with and without adjustment for mammographic breast density

Risk ratio (95% CI)
StratumFamily historyCases/totalMultivariable, without densityaMultivariable, with densityb
Age 40Simple
 No first-degree history123/74,0241.0 (Ref)1.0 (Ref)
 First-degree family history41/14,6921.5 (1.0–2.1)1.5 (1.0–2.1)
 No family history78/51,2751. (Ref)1. (Ref)
 Second degree only45/22,4461.3 (0.84–1.9)1.3 (0.84–1.9)
 First degree only20/8,7741.4 (0.85–2.2)1.4 (0.84–2.2)
 First and second degree20/5,7421.9 (1.1–3.2)1.9 (1.1–3.2)
 Male relative1/4790.91 (0.09–9.5)0.90 (0.09–9.4)
Age 50Simple
 No first-degree history523/158,5581. (Ref)1. (Ref)
 First-degree family history181/34,4221.5 (1.3–1.7)1.5 (1.3–1.7)
 No family history362/116,8661. (Ref)1. (Ref)
 Second degree only160/41,0281.2 (1.0–1.4)1.2 (1.0–1.4)
 First degree only110/21,1651.5 (1.2–1.8)1.5 (1.2–1.7)
 First and second degree69/12,8241.7 (1.3–2.1)1.6 (1.3–2.0)
 Male relative3/1,0971.4 (0.58–3.2)1.4 (0.58–3.2)
Age 60Simple
 No first-degree history659/137,5241. (Ref)1. (Ref)
 First-degree family history254/35,9461.4 (1.2–1.6)1.4 (1.2–1.6)
 No family history493/105,4871. (Ref)1. (Ref)
 Second degree only161/31,3851.1 (0.93–1.3)1.1 (0.91–1.3)
 First degree only160/23,0081.4 (1.2–1.7)1.4 (1.2–1.7)
 First and second degree91/12,4881.4 (1.2–1.7)1.4 (1.1–1.7)
 Male relative8/1,1021.7 (0.84–3.4)1.7 (0.82–3.3)
Age 70Simple
 No first-degree history484/70,7041. (Ref)1. (Ref)
 First-degree family history191/20,4851.3 (1.1–1.5)1.2 (1.1–1.5)
 No family history396/56,7521. (Ref)1. (Ref)
 Second degree only86/13,5540.95 (0.76–1.2)0.93 (0.75–1.2)
 First degree only134/14,0951.3 (1.05–1.5)1.3 (1.0–1.5)
 First and second degree52/6,0871.2 (0.88–1.5)1.1 (0.85–1.5)
 Male relative7/7011.7 (0.80–3.4)1.6 (0.78–3.3)
  • NOTE: Women with a male relative affected by breast cancer were placed in the male relative category regardless of breast cancer among female relatives.

  • aAdjusted for age, age squared, BMI, BMI squared, race/ethnicity, and registry.

  • bAdjusted for age, age squared, BMI, BMI squared, race/ethnicity, registry, and BI-RADS density category.