Table 2.

Summary of gene regions significantly associated with more than one cancer

Candidate genesSelect regionSNPs/region (N)Associated SNPs (N)aAssociated cancersStrongest associationPreviously in GWAS associated cancersb
RUVBL13: 127733628-12792275734627 (1)Endometrioid ovarian cancer, overall prostate cancer, colorectal cancerEndometrioid ovarian cancer, overall prostate cancer: rs144609957 - OR: 1.13; 95% CI: 1.08–1.19; P: 3.44 × 10−7Prostate cancer
TET24: 106017842-1062509605739 (3)Overall prostate cancer, overall ovarian cancer, endometrioid ovarian cancer, overall breast cancer, clear cell ovarian cancer, colorectal cancerOverall prostate cancer, endometrioid ovarian cancer: rs6839705 - OR: 1.11; 95% CI: 1.07–1.16; P: 3.32 × 10−7Prostate cancer, breast cancer
L3MBTL36: 130289728-13051259459011 (2)Colorectal cancer, overall breast cancer, ER-negative breast cancer, clear cell ovarian cancer, overall prostate cancer, aggressive prostate cancerColorectal cancer, overall breast cancer, ESR1 (ER)-negative breast cancer, clear cell ovarian cancer, overall prostate cancer, aggressive prostate cancer: rs9388766 - OR 1.06; 95% CI: 1.03–1.08; P: 1.07 × 10−6None
HDAC97: 18076572-1875846613071 (1)Lung adenocarcinoma, squamous cell lung cancer, colorectal cancer, clear cell ovarian cancerLung adenocarcinoma, squamous cell lung cancer, colorectal cancer, clear cell ovarian cancer: rs190505819 - OR: 1.88; 95% CI: 1.44–2.45; P: 2.95 × 10−6None
BRCA213: 32839617-330238091961 (1)Overall lung cancer, squamous cell lung cancer, colorectal cancerOverall lung cancer, squamous cell lung cancer, colorectal cancer: rs56404467 - OR: 1.30; 95% CI: 1.15–1.48; P: 3.26 × 10−5Breast cancer, lung cancer
MORF4L115: 79115123-7924008132715 (2)Overall lung cancer, lung adenocarcinoma, squamous cell lung cancer, clear cell ovarian cancerOverall lung cancer, lung adenocarcinoma, clear cell ovarian cancer: rs7179953 - OR: 0.93; 95% CI: 0.91–0.96; P: 5.34 × 10−7Lung cancer
BABAM119: 17328232-1744381140433 (5)Squamous cell lung cancer, ER-negative breast cancer, serous ovarian cancer, overall breast cancer, overall ovarian cancer, overall prostate cancerSquamous cell lung cancer, ESR1 (ER)-negative breast cancer, serous ovarian cancer: rs4808076 - OR: 1.14; 95% CI: 1.10–1.19; P: 1.77 × 10−10Breast cancer, ovarian cancer
DPF119: 38651649-387703172842 (1)Overall prostate cancer, ESR1 (ER)-negative breast cancer, endometrioid ovarian cancer, aggressive prostate cancerOverall prostate cancer, ESR1 (ER)-negative breast cancer, endometrioid ovarian cancer, aggressive prostate cancer: rs12611084 - OR 0.93; 95% CI: 0.91–0.96; P: 8.40 × 10−8Prostate cancer
  • Abbreviations: CI, confidence interval; ER, estrogen receptor; Nr, number.

  • aIndependent associations.

  • bAssociated with breast, colorectal, lung, ovarian, or prostate cancer.