Table 4.

Reclassification of TP53 mutation carriers using LFSPRO

CarriersNoncarriers
LFSPROPr ≥ 0.2Pr < 0.2Pr ≥ 0.2Pr < 0.2Reclassification ratea
MDACC
 Classic
  +40b01c11.0%
  –16c1214b234
 Chompret
  +113b311c12.1%
  –9c911b224
ISKS
 Classic
  +20b10c2.6%
  –4c1912b575
 Chompret
  +37b232c8.6%
  –3c1211b543
NCI
 Classic
  +230b10c49.7%
  –146c4182b166
 Chompret
  +9418b68c38.8%
  –75c2377b158
  • aReclassification rate is defined as the percentage of individuals that were classified differently by LFSPRO (categories b and c) as compared with the other criteria.

  • bThe clinical criteria corrected classifications of carrier or noncarrier, as compared with LFSPRO.

  • cLFSPRO corrected classifications of carrier or noncarrier, as compared with clinical criteria.