Table 3.

Recent alcohol intake and invasive breast cancer by study from the AMBER consortium

ControlsCasesBasic modelaControlsCasesMV modelb
N (%)N (%)OR (95% CI)N (%)N (%)OR (95% CI)
CBCS
Number of alcoholic drinks per week
 Never drinkers309 (39.4)293 (37.5)1.16 (0.90–1.50)258 (39.0)253 (37.5)1.23 (0.92–1.65)
 >0–<4232 (29.6)193 (24.7)Ref.199 (30.0)166 (24.6)Ref.
 ≥4–<744 (5.6)32 (4.1)0.88 (0.53–1.43)36 (5.4)28 (4.2)0.95 (0.55–1.64)
 ≥754 (6.9)88 (11.3)2.02 (1.37–2.99)46 (6.9)72 (10.7)2.03 (1.29–3.18)
 Past drinkers145 (18.5)75 (22.4)1.50 (1.11–2.03)123 (18.6)155 (23.0)1.53 (1.09–2.14)
  Ptrendc<0.010.01
WCHS
Number of alcoholic drinks per week
 Never drinkers791 (65.1)798 (65.4)0.96 (0.72–1.27)742 (66.0)727 (65.1)0.89 (0.66–1.21)
 >0–<4111 (9.1)113 (9.3)Ref.101 (8.9)104 (9.3)Ref.
 ≥4–<743 (3.5)40 (3.3)0.91 (0.55–1.51)37 (3.3)38 (3.4)1.01 (0.59–1.73)
 ≥760 (4.9)53 (4.3)0.84 (0.53–1.32)57 (5.1)50 (4.5)0.81 (0.51–1.31)
 Past drinkers211 (17.4)216 (17.7)0.96 (0.70–1.34)187 (16.6)198 (17.7)0.98 (0.69–1.39)
  Ptrendc0.420.40
MEC
Number of alcoholic drinks per week
 Never drinkers2,360 (53.3)629 (55.5)1.07 (0.90–1.27)1,908 (51.4)478 (53.0)1.10 (0.91–1.34)
 >0-<4906 (20.5)226 (19.9)Ref.759 (20.5)183 (20.3)Ref.
 ≥4–<7174 (3.9)43 (3.8)0.99 (0.69–1.43)150 (4.0)32 (3.6)0.92 (0.60–1.39)
 ≥7451 (10.2)129 (11.4)1.15 (0.90–1.47)411 (11.8)108 (12.0)1.06 (0.81–1.40)
 Past drinkers540 (12.2)107 (9.4)0.79 (0.62–1.03)481 (13.0)101 (11.2)0.87 (0.66–1.14)
  Ptrendc0.290.63
BWHS
Number of alcoholic drinks per week
 Never drinkers4,056 (37.6)797 (40.5)1.15 (1.02–1.30)3,568 (37.9)676 (40.8)1.17 (1.02–1.34)
 >0–<42,865 (26.6)491 (24.9)Ref.2,480 (26.3)409 (24.7)Ref.
 ≥4–<7615 (5.7)108 (5.5)1.02 (0.82–1.28)527 (5.6)94 (5.7)1.08 (0.85–1.38)
 ≥7486 (4.5)98 (5.0)1.17 (0.92–1.49)414 (4.4)78 (4.7)1.13 (0.87–1.48)
 Past drinkers2,765 (25.6)475 (24.1)0.99 (0.87–1.14)2,433 (25.8)399 (24.1)1.02 (0.88–1.19)
  Ptrendc0.230.38

Abbreviation: CI, confidence interval.

  • aBasic model adjusted for age, study, time period, and geographic region.

  • bMultivariable model adjusted for age, study, time period, geographic region, education, age at menarche, BMI, menopausal status (pre-/post-), HT use (ever/never), parity, smoking status, and duration of oral contraceptive use.

  • cPtrend excludes never and past drinkers.