Table 2.

Recent alcohol intake in relation to Hormone Receptor status among invasive breast cancer cases in the AMBER consortium

Controls N (%)Cases N (%)Basic modela OR (95% CI)Controls N (%)Cases N (%)MV modelb OR (95% CI)Cases N (%)Basic modela OR (95% CI)Cases N (%)MV modelb OR (95% CI)
Drinks per weekAll invasive breast cancer
 Never drinkers7,516 (43.7)2,517 (49.3)1.12 (1.03–1.22)6,476 (43.4)2,134 (49.1)1.12 (1.02–1.24)
 >0–<44,114 (23.9)1,023 (20.0)Ref.3,539 (23.7)862 (19.8)Ref.
 ≥4–<7876 (5.1)223 (4.4)0.99 (0.84–1.17)750 (5.0)192 (4.4)1.04 (0.86–1.25)
 ≥7–<14605 (3.5)190 (3.7)1.13 (0.94–1.36)534 (3.6)159 (3.7)1.07 (0.88–1.32)
 ≥14446 (2.6)178 (3.5)1.34 (1.10–1.63)394 (2.6)149 (3.4)1.33 (1.07–1.64)
 Past drinkers3,661 (21.3)973 (19.1)1.01 (0.91–1.12)3,224 (21.6)853 (19.6)1.04 (0.93–1.17)
  Ptrendc0.010.09
Drinks per weekER+ER
 Never drinkers7,516 (43.7)1,259 (49.4)1.10 (0.98–1.23)6,476 (43.4)1,072 (48.9)1.13 (0.99–1.29)638 (46.3)1.12 (0.96–1.30)536 (45.7)1.07 (0.90–1.27)
 >0–<44,114 (23.9)508 (19.9)Ref.3,539 (23.7)428 (19.5)Ref.297 (21.5)Ref.254 (21.7)Ref.
 ≥4–<7876 (5.1)109 (4.3)0.98 (0.78–1.23)750 (5.0)98 (4.5)1.10 (0.86–1.40)61 (4.4)0.97 (0.72–1.31)53 (4.5)1.02 (0.74–1.41)
 ≥71,051 (6.1)189 (7.4)1.20 (1.00–1.45)928 (6.2)161 (7.3)1.20 (0.97–1.47)111 (8.1)1.35 (1.06–1.72)91 (7.8)1.31 (1.00–1.72)
 Past drinkers3,661 (21.3)484 (19.0)0.99 (1.00–1.45)3,224 (21.6)434 (19.8)1.07 (0.92–1.24)272 (19.7)1.11 (0.92–1.33)238 (20.3)1.11 (0.91–1.35)
  Ptrendc0.120.180.030.08
Drinks per weekPR+PR
 Never drinkers7,516 (43.7)1,001 (49.5)1.12 (0.99–1.28)6,476 (43.4)852 (48.8)1.14 (0.98–1.32)825 (47.0)1.10 (0.96–1.26)688 (46.6)1.07 (0.92–1.25)
 >0–<44,114 (23.9)395 (19.5)Ref.3,539 (23.7)336 (19.2)Ref.377 (21.5)Ref.318 (21.5)Ref.
 ≥4–<7876 (5.1)77 (3.8)0.87 (0.67–1.13)750 (5.0)72 (4.1)1.02 (0.77–1.35)82 (4.7)1.04 (0.80–1.35)70 (4.7)1.08 (0.81–1.43)
 ≥71,051 (6.1)142 (7.0)1.18 (0.95–1.45)928 (6.2)121 (6.9)1.19 (0.95–1.50)138 (7.9)1.32 (1.06–1.64)112 (7.6)1.28 (1.00–1.63)
 Past drinkers3,661 (21.3)406 (20.1)1.07 (0.95–1.46)3,224 (21.6)366 (21.0)1.14 (0.97–1.35)333 (19.0)1.02 (0.87–1.20)290 (19.6)1.04 (0.88–1.25)
  Ptrendc0.300.290.030.08
Drinks per weekHER2+HER2
 Never drinkers7,516 (43.7)254 (46.8)1.01 (0.80–1.28)6,476 (43.4)212 (45.8)0.93 (0.72–1.21)1,007 (46.9)1.01 (0.88–1.15)857 (46.4)1.04 (0.90–1.21)
 >0–<44,114 (23.9)115 (21.2)Ref.3,539 (23.7)101 (21.8)Ref.436 (20.3)Ref.367 (19.9)Ref.
 ≥4–<7876 (5.1)31 (5.7)1.21 (0.80–1.83)750 (5.0)28 (6.0)1.34 (0.87–2.09)87 (4.1)0.91 (0.70–1.18)79 (4.3)1.04 (0.79–1.37)
 ≥71,051 (6.1)44 (8.1)1.33 (0.93–1.92)928 (6.2)33 (7.1)1.17 (0.77–1.77)169 (7.9)1.27 (1.03–1.56)149 (8.0)1.36 (1.09–1.70)
 Past drinkers3,661 (21.3)99 (18.2)0.94 (0.72–1.25)3,224 (21.6)89 (19.2)0.99 (0.73–1.73)450 (20.9)1.08 (0.93–1.26)398 (21.5)1.15 (0.99–1.37)
  Ptrendc0.060.380.050.01
Drinks per weekNon triple negativeTriple negative
 Never drinkers7,516 (43.7)2,195 (50.3)1.14 (1.04–1.25)6,476 (43.4)1,867 (50.1)1.14 (1.03–1.26)322 (43.4)0.97 (0.77–1.20)267 (42.7)0.96 (0.76–1.22)
 >0–<44,114 (23.9)859 (19.7)Ref.3,539 (23.7)725 (19.5)Ref.164 (22.1)Ref.137 (21.9)Ref.
 ≥4–<7876 (5.1)188 (4.3)0.99 (0.82–1.18)750 (5.0)161 (4.3)1.02 (0.84–1.24)35 (4.7)1.01 (0.68–1.51)31 (5.0)1.14 (0.74–1.74)
 ≥71,051 (6.1)305 (7.0)1.21 (1.04–1.40)928 (6.2)255 (6.9)1.16 (0.98–1.37)63 (8.5)1.39 (1.01–1.92)53 (8.5)1.39 (0.98–2.00)
 Past drinkers3,661 (21.3)815 (18.7)0.99 (0.89–1.11)3,224 (21.6)716 (19.2)1.02 (0.91–1.15)158 (21.3)1.19 (0.93–1.50)137 (21.9)1.21 (0.93–1.58)
  Ptrendc0.040.180.060.06

Abbreviation: CI, confidence interval.

  • aBasic model adjusted for age, study, time period, and geographic region.

  • bMultivariable model adjusted for age, study, time period, geographic region, education, age at menarche, BMI, menopausal status (pre-/post-), HT use (ever/never), parity, smoking status, and duration of oral contraceptive use.

  • cPtrend excludes never and past drinkers.