Table 1.

Design and assays used in preapproval studies

	Study 1	Study 2	Study 3
Study name	Specificity	Cutoff	DeeP-C
Design	Cohort	Case–control	Cohort
Participants	Low-risk patients, recruited after negative colonoscopy	Cases referred for surveillance or known colorectal neoplasm, asymptomatic average-risk controls	Average-risk patients due for CRC screening
Methylated DNA markers	BMP3^a NDRG4^a TFPI2 Vimentin	BMP3^a NDRG4^a	BMP3^a NDRG4^a
Mutant DNA markers	—	KRAS	KRAS
Normalizing DNA marker	β-Actin^a	β-Actin^a	β-Actin^a
FIT	—	Yes	Yes

Abbreviation: CRC, colorectal cancer.
↵^aMarkers used in calibrated analysis.