Table 2.

Descriptive statistics of population-based families from the Colon Cancer Family Registry by mismatch repair (MMR) gene and MUTYH mutation carrier status

MMR gene mutation families (n = 136)MUTYH mutation families (n = 81)Noncarrier/unidentified carrier status families (n = 5528)
Relative of probandTotal no.No. of CRC affected (%)Mean age at CRC diagnosis (SD)Total no.No. of CRC affected (%)Mean age at CRC diagnosis (SD)Total no.No. of CRC affected (%)Mean age at CRC diagnosis (SD)
Proband136136 (100)42.9 (10.5)8181 (100)50.1 (12.3)5,5285,528 (100)52.7 (11.5)
Father13626 (19)49.0 (14.4)818 (10)67.8 (7.0)5,501a271 (5)62.7 (10.0)
Mother13616 (12)51.4 (12.6)810 (0)5,501a218 (4)62.3 (11.7)
Sibling37527 (8)41.7 (11.5)1814 (2)63.3 (9.9)14,494224 (2)57.6 (12.5)
Offspring2070 (0)1500 (0)10,66512 (0.1)40.3 (14.4)
  • NOTE: One proband had both an MMR gene and a monoallelic MUTYH germline mutation.

  • Abbreviation: CRC, colorectal cancer.

  • a7 probands had no data for father and mother.