Table 2.

Results obtained from examining the association between survival and mdNLR among the Bladder and HNSCC studies

StudyVariableHR (95% CI)P
HNSCC
mdNLR (cont.)2.58 (1.41–4.71)0.002a
Age1.05 (1.02–1.08)2.9 × 10−4a
Gender
 Femaleref (N/A)N/A
 Male0.71 (0.38–1.31)0.270
Smoking history
 Neverref (N/A)N/A
 Ever45.72 (3.22–648.56)0.005a
Tumor site
 Laryngealref (N/A)N/A
 Oral cavity1.13 (0.53–2.43)0.744
 Oropharyngeal2.7 (1.13–6.43)0.025b
 HPV160.17 (0.07–0.42)1.2 × 10−4a
Tumor stage
 Stage Iref (N/A)N/A
 Stages II, III, IV2.53 (0.97–6.6)0.058c
 Smoking × mdNLR0.41 (0.22–0.78)0.006d
HNSCC
mdNLR
 mdNLR ≤ 5
 mdNLR > 513.87 (2.76–69.66)0.001a
Age1.05 (1.02–1.08)4.9 × 10−4a
Gender
 Female
 Male0.71 (0.38–1.33)0.283
Smoking history
 Never
 Ever3.05 (1.1–8.45)0.032b
Tumor site
 Laryngeal
 Oral cavity1.19 (0.56–2.54)0.646
 Oropharyngeal2.45 (1.01–5.92)0.047b
 HPV160.2 (0.08–0.48)2.9 × 10−4a
Tumor stage
 Stage I
 Stages II, III, IV2.31 (0.88–6.1)0.090c
 Smoking × mdNLR0.1 (0.02–0.63)0.014b
Bladder
mdNLR (cont.)1.65 (1.15–2.37)0.007d
Age1.07 (1.04–1.10)2.3 × 10−6a
 Gender
 Femaleref (N/A)N/A
 Male1.62 (0.96–2.74)0.070c
Smoking history
 Neverref (N/A)N/A
 Ever4.98 (1.44–17.17)0.011b
Tumor stage
 Low (T0a & T1–T3)ref (N/A)N/A
 High (Tis & T4)2.75 (1.45–5.20)0.002a
 Smoking × mdNLR0.67 (0.46–0.97)0.033b
Bladder
mdNLR
 mdNLR ≤ 5ref (N/A)N/A
 mdNLR > 533.67 (6.77–167.5)1.7 × 10−5a
Age1.08 (1.05–1.11)1.7 × 10−7a
Gender
 Femaleref (N/A)N/A
 Male1.61 (0.95–2.72)0.076c
Smoking history
 Neverref (N/A)N/A
 Ever1.97 (1.09–3.55)0.024b
Tumor stage
 Low (T0a & T1-T3)ref (N/A)N/A
 High (Tis & T4)3.29 (1.73–6.27)2.8 × 10−4a
 Smoking × mdNLR0.08 (0.01–0.42)0.003a